Chemokines and neuromodulation
Chemokines and neuromodulation
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DOI：
10.1016/j.jneuroim.2008.04.022
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发表时间：
2008-07-31
影响因子：
3.3
通讯作者：
Rostene, William
中科院分区：
文献类型：
--
作者：
Melik-Parsadaniantz, Stephane;Rostene, William
趋化因子不仅是免疫系统的介质并且在炎症情况下表达。它们也在大脑中的神经胶质细胞和神经元中组成型表达。最近的一些证据表明，它们对大脑功能具有神经递质/神经调节作用，类似于迄今为止报道的几种神经肽。这篇简短综述的目的是使用两种趋化因子系统 SDF-1/CXCL12 及其受体 CXCR4 和 MCP-1/CCL2 及其受体 CCR2 来说明这一点。 (C) 2008 Elsevier B.V. 保留所有权利。
Chemokines are not only mediators of the immune system and expressed in inflammatory situations. They are also Constitutively expressed in the brain in both glial cells and neurons. Several recent evidence suo est that they can have a neurotransmitter/neuromodulatory role on brain functions similar to several neuropeptides reported so far. The aim of this short review is to illustrate that point using two chemokine systems, SDF-1/CXCL12 and its receptor CXCR4 and MCP-1/CCL2 and its receptor CCR2. (C) 2008 Elsevier B.V. All rights reserved.