Epigenetics of Colorectal Cancer
Epigenetics of Colorectal Cancer
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DOI：
10.1007/978-1-4939-1804-1_22
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发表时间：
2015-01-01
期刊：
影响因子：
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通讯作者：
Guo, Mingzhou
中科院分区：
文献类型：
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作者：
Yan, Wenji;Guo, Mingzhou
结直肠癌（CRC）是最常见的恶性肿瘤之一，也是全球癌症相关死亡的主要原因。表观遗传改变是结直肠癌发生的重要机制。在结直肠癌和其他肿瘤中发现了表观遗传变化的积累。 DNA 甲基化、组蛋白修饰、印记和非编码 RNA 的异常变化在人类结直肠癌中经常被发现。表观遗传变化可作为诊断、预后和化学敏感标记。在某些情况下，它也成为癌症预防或治疗的目标。
Colorectal cancer (CRC) is one of most common malignancies and a leading cause of cancer related deaths worldwide. Epigenetic change is an important mechanism of colorectal carcinogenesis. Accumulation of epigenetic changes was found in colorectal cancer and other tumors. Aberrant changes in DNA methylation, histone modification, imprinting, and noncoding RNAs were frequently found in human colorectal cancer. Epigenetic changes may serve as a diagnostic, prognostic, and chemo-sensitive marker. It also becomes a cancer preventive or therapeutic target in some circumstances.