Building models using Reactome pathways as templates.
Building models using Reactome pathways as templates.
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DOI：
10.1007/978-1-62703-450-0_14
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发表时间：
2013-01-01
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影响因子：
--
通讯作者：
Croft, David
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作者：
Croft, David
构建新模型的第一步可能非常耗时，需要查阅许多研究论文，然后组装一个合理的反应网络。本章将讨论加速这一过程的工具。 Reactome 是一个数据库，包含广泛的智人途径和众多参考物种。它为希望从头开始创建新模型的研究人员提供了各种工具来提取相关反应，并提供完整的布局信息。本章将描述两个用例，其中建模者提供某些基本信息，Reactome 自动构建基本模型，然后将其转储为 SBML-ML 格式。
The first steps of building a new model can be very time-consuming, involving consulting many research papers and then assembling a plausible network of reactions. In this chapter, tools for speeding up this process will be discussed. Reactome is a database containing extensive coverage of pathways in Homo sapiens and numerous reference species. It offers researchers wishing to create new models from scratch various tools for extracting the relevant reactions, complete with layout information. In this chapter, two use cases will be described, in which a modeller provides certain essential pieces of information and Reactome automatically constructs the basic models and then dumps them in SBML-ML format.