Nutritional programming by glucocorticoids in breast milk: Targets, mechanisms and possible implications
Nutritional programming by glucocorticoids in breast milk: Targets, mechanisms and possible implications
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DOI：
10.1016/j.beem.2017.10.001
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发表时间：
2017-08-01
影响因子：
7.4
通讯作者：
Finken, Martijn J. J.
中科院分区：
文献类型：
--
作者：
Hollanders, Jonneke J.;Heijboer, Annemieke C.;Finken, Martijn J. J.
糖皮质激素通过母乳的垂直传播可能会形成一种机制，通过这种机制，哺乳期妇女可以让她们的婴儿为产后环境做好准备。母乳糖皮质激素的主要来源可能是体循环。我们小组的研究表明，乳汁中的皮质醇和可的松浓度遵循母体下丘脑-垂体-肾上腺轴活动的昼夜节律，可的松的丰度高于皮质醇。由于可能与孕激素和性类固醇发生交叉反应，母乳糖皮质激素浓度的测量具有挑战性，孕激素和性类固醇在怀孕期间和分娩后会严重升高。这需要不受交叉反应性阻碍的精确方法，如LC-MS/MS。有一些数据表明，母乳糖皮质激素可以促进肠道的局部成熟，也可以在被吸收进入体循环后促进肠道成熟。母乳中的糖皮质激素也可能对肠道微生物群有影响，尽管到目前为止还没有研究。研究母乳糖皮质激素的全身作用的研究结果很难解释，因为没有人考虑到母乳中糖皮质激素的昼夜节律，并且使用了各种分析方法。然而，母乳中的糖皮质激素可能为母亲向婴儿传递信号提供了一种新的潜在途径。(C) 2017 Elsevier Ltd.版权所有。
Vertical transmission of glucocorticoids via breast milk might pose a mechanism through which lactating women could prepare their infants for the postnatal environment. The primary source of breast milk glucocorticoids is probably the systemic circulation. Research from our group showed that milk cortisol and cortisone concentrations follow the diurnal rhythm of maternal hypothalamus-pituitary-adrenal axis activity, with a higher abundance of cortisone compared to cortisol. Measurement of breast-milk glucocorticoid concentrations is challenging due to possible cross-reactivity with progestagens and sex steroids, which are severely elevated during pregnancy and after parturition. This requires precise methods that are not hindered by cross reactivity, such as LC-MS/MS. There are some data suggesting that breast-milk glucocorticoids could promote intestinal maturation, either locally or after absorption into the systemic circulation. Breast-milk glucocorticoids might also have an effect on the intestinal microbiome, although this has not been studied thus far. Findings from studies investigating the systemic effects of breast-milk glucocorticoids are difficult to interpret, since none took the diurnal rhythm of glucocorticoids in breast milk into consideration, and various analytical methods were used. Nevertheless, glucocorticoids in breast milk might offer a novel potential pathway for signal transmission from mothers to their infants. (C) 2017 Elsevier Ltd. All rights reserved.