Enhancing the survival of aspirated human fat injected into nude mice
Enhancing the survival of aspirated human fat injected into nude mice
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DOI：
10.1097/00006534-199806000-00026
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发表时间：
1998-06-01
影响因子：
3.6
通讯作者：
Lindenbaum, ES
中科院分区：
文献类型：
--
作者：
Ullmann, Y;Hyams, M;Lindenbaum, ES
注射吸入脂肪是目前最常用的填充凹陷区域的技术。注射脂肪的部分吸收是这一过程的主要限制。Cariel T.M.是一种浓缩的无血清细胞培养液，在裸鼠模型中研究了其提高人吸入性脂肪移植物存活的能力。实验组16只裸鼠头皮下注射0.75毫升Cariel预处理脂肪，对照组15只注射等量生理盐水。在这个新使用的模型中，在15周后，观察到显著的体重维持，实验组为46%，对照组为29%(p<；0.008)，体积，实验组为44%，对照组为31%(p<；0.026)。似乎添加了富含合成激素的营养物质能够使移植物中更多的脂肪细胞存活和摄取。
Injection of aspirated fat is now the most commonly used technique for the filling of depressed areas. Partial absorption of the injected fat is the main limitation of this procedure. Cariel T.M. is an enriched serum-free cell culture medium, its ability to enhance the survival of human aspirated fat grafts was investigated in the nude mouse model. A volume of 0.75-cc Cariel preprocessed fat was injected under the scalp skin of 16 nude mice in the experimental group, and the same volume of saline preprocessed fat was injected to 15 control group of mice. Significant maintenance of the weight, 46 percent in the experimental group compared with 29 percent in the control group (p < 0.008), and the volume, 44 percent in the experimental group compared with 31 percent in the control group (p < 0.026), was observed, after 15 weeks, in this newly used model. It seems that addition of the nutrients enriched with anabolic hormones enabled the survival and take of more adipose cells in the graft.