Expression of vascular endothelial growth factor (VEGF) in locally invasive prostate cancer is prognostic for radiotherapy outcome
Expression of vascular endothelial growth factor (VEGF) in locally invasive prostate cancer is prognostic for radiotherapy outcome
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DOI：
10.1016/j.ijrobp.2006.08.077
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发表时间：
2007-01-01
影响因子：
7
通讯作者：
Stratford, Ian J.
中科院分区：
文献类型：
--
作者：
Green, Melanie M. L.;Hiley, Crispin T.;Stratford, Ian J.
目的：血管内皮生长因子（VEGF）是一种重要的缺氧诱导促血管生成蛋白，与其他癌症类型放疗后的不良生存结局有关：我们假设这也可能发生在前列腺癌中。因此，进行了一项回顾性研究，以评估潜在的肿瘤VEGF的表达，以预测放射治疗的结果在高危前列腺癌patients with high-risk prostate cancer.Methods和Materials：50例局部晚期（T3 N 0 M0）肿瘤的Gleason评分>= 6，并接受单独的放射治疗作为主要治疗他们的疾病，进行了研究。使用血清定量免疫组织化学评分系统评估治疗前诊断性肿瘤活检中血管内皮生长因子的表达。结果进行了分析有关的临床病理因素和患者的结果，包括生化故障和疾病特异性mortals.Results：高VEGF表达与预后不良：在单变量对数秩分析，VEGF是唯一显着的预后因素疾病特异性生存（p = 0.035）。高VEGF表达也与Gleason评分增加（p = 0.02），但不治疗后生化failure.Conclusion：高肿瘤VEGF表达的患者在高风险的治疗失败与放射治疗。这些患者可能受益于其他治疗方法，包括抗血管生成或缺氧特异性药物。(c)2007年爱思唯尔公司
Purpose: Vascular endothelial growth factor (VEGF) is an important hypoxia-inducible pro-angiogenic protein that has been linked with an adverse survival outcome after radiotherapy in other cancer types: we hypothesized that this may also occur in prostate cancer. A retrospective study was, therefore, carried out to evaluate the potential of tumor VEGF expression to predict radiotherapy outcome in patients with high-risk prostate cancer.Methods and Materials: Fifty patients with locally advanced (T3 N0 M0) tumors of Gleason score >= 6, and who received radiotherapy alone as primary treatment for their disease, were studied. Vascular endothelial growth factor expression was assessed on pretreatment diagnostic tumor biopsies using a serniquantitative immunohistochemical scoring system. The results were analyzed in relation to clinicopathologic factors and patient outcome including biochemical failure and disease-specific mortality.Results: High VEGF expression was associated with a poor prognosis: in univariate log rank analysis, VEGF was the only significant prognostic factor for disease-specific survival (p = 0.035). High VEGF expression also associated with increased Gleason score (p = 0.02), but not posttreatment biochemical failure.Conclusion: High tumor expression of VEGF identified patients at high risk of failure of treatment with radiotherapy. These patients might benefit from additional treatment approaches incorporating anti-angiogenic or hypoxia-specific agents. (c) 2007 Elsevier Inc.