Lack of association between HLA and age in an aging population.
Lack of association between HLA and age in an aging population.
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在老龄化人口中，HLA 与年龄之间缺乏关联。
DOI：
10.1111/j.1399-0039.1982.tb00344.x
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
F. Payne
中科院分区：
文献类型：
--
作者：
W. Blackwelder;K. Mittal;P. McNamara;F. Payne
在228名年龄在58岁到86岁之间的弗雷明汉研究参与者的HLA分型样本中，个体抗原的频率和a或B位点的杂合性似乎都与年龄无关。先前发现的关联可能是偶然发生的，或者hla对普通人群寿命的影响可能很小。也有可能这种影响发生在比我们研究中包括的年龄更小的人身上，或者HLA与衰老过程的关系只有在非常年老的时候才能检测到。
In a sample of 228 Framingham Study participants aged 58 to 86 who were typed for HLA, neither frequencies of individual antigens nor heterozygosity at the A or B loci appeared to be related to age. Previously found associations could be chance occurrences, or HLA-related effects on longevity in the general population might be small. It is also possible that such effects occur at younger ages than those included in our study or that HLA is related to the aging process in a way that is detectable only at very advanced ages.