Endocan Expression Correlated with Poor Survival in Human Hepatocellular Carcinoma
Endocan Expression Correlated with Poor Survival in Human Hepatocellular Carcinoma
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DOI：
10.1007/s10620-008-0346-3
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发表时间：
2009-02-01
影响因子：
3.1
通讯作者：
Ding, Xiang
中科院分区：
文献类型：
--
作者：
Huang, Geng-Wen;Tao, Yi-Ming;Ding, Xiang
肝细胞癌（HCC）是我国第二大恶性肿瘤死亡原因。我们的目的是首次提出肝癌组织中内皮聚糖的表达及其与肝癌患者的临床病理特征和根治性肝切除术后的总生存率的相关性。免疫组化检测100例HCC患者的内皮聚糖、CD 34和血管内皮生长因子（VEGF）。Endocan蛋白在所有肝癌组织的内皮细胞中均有表达，而在癌旁肝组织和正常肝组织中未见表达。微血管密度（MVD）与微静脉浸润和VEGF表达相关（P < 0.05）。生存分析显示，患者的总生存率与内皮素-MVD呈负相关（P < 0.01）。多因素分析显示，内皮癌MVD是影响肝癌总生存率的独立预后指标（P < 0.01）。总之，内皮癌MVD是预测肝癌根治性切除术后患者预后的一个重要因素。
Hepatocellular carcinoma (HCC) is the second leading cause of cancer death in China. We aimed to first present the expression of endocan in HCC tissue and its correlation with the clinicopathological features and overall survival of patients with HCC after curative hepatectomy. Immunohistochemical detection of endocan, CD34, and vascular endothelial growth factor ( VEGF) were performed on samples from 100 patients with HCC. Endocan protein was expressed in endothelium of HCC tissue in all specimens, but was not expressed in endothelium of pericarcinomatous liver tissue and normal liver tissue. Microvessel density (MVD) denoted by endocan (endocan-MVD) in HCC was correlated with microscopic venous invasion and VEGF expression (P < 0.05). Survival analysis showed that overall survival of patients was inversely associated with endocan-MVD (P < 0.01). Multivariate analysis showed that endocan-MVD was an independent prognostic marker for overall survival of HCC (P < 0.01). In conclusion, endocan-MVD was a significant factor to predict the prognosis of HCC patients after curative hepatectomy.