High-resolution intravascular magnetic resonance quantification of atherosclerotic plaque at 3T.
High-resolution intravascular magnetic resonance quantification of atherosclerotic plaque at 3T.
复制标题
3T 下动脉粥样硬化斑块的高分辨率血管内磁共振定量。
DOI：
10.1186/1532-429x-14-20
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发表时间：
2012-03-26
期刊：
影响因子：
--
通讯作者：
Bottomley PA
中科院分区：
文献类型：
--
作者：
Qian D;Bottomley PA
动脉粥样硬化病变的纤维帽（FCT）厚度是影响斑块破裂脆弱性的关键因素。本研究测试是否3特斯拉的高分辨率血管内心血管磁共振（CMR）采用微小的无环探测器可以识别病变和准确地测量FCT在人体动脉标本，以及这种方法是否是可行的，在体内使用动物模型。为临床3特斯拉MR扫描仪制造了仅接收的2.2 mm和0.8 mm直径血管内无环CMR探测器，并确定了绝对信噪比。在两步方案中应用探测器，包括CMR血管造影以识别动脉粥样硬化病变，然后进行高分辨率CMR以表征FCT、病变大小和/或血管壁厚度。该方案应用于人体等效盐水浴中的新鲜人髂动脉和颈动脉标本。将通过80 μ m血管内CMR测量的平均FCT与相同切片的组织学进行比较。体内研究比较了健康和高血压兔模型的主动脉壁厚度和斑块大小，并进行了死后组织学检查。组织学证实了人体标本中的斑块，钙化表现为信号空洞。平均FCT与组织学测量值的一致性平均在13%以内（相关系数，R = 0.98; Bland-Altman分析，-1.3 ±68.9 μ m）。80 μ m血管内CMR测量的在体主动脉壁和斑块大小与组织学一致。无环探测器的血管内3T CMR可以定位动脉粥样硬化病变，并以高分辨率准确测量FCT，这在体内是可行的。该方法显示了量化易损斑块以评估实验治疗的前景。
The thickness of fibrous caps (FCT) of atherosclerotic lesions is a critical factor affecting plaque vulnerability to rupture. This study tests whether 3 Tesla high-resolution intravascular cardiovascular magnetic resonance (CMR) employing tiny loopless detectors can identify lesions and accurately measure FCT in human arterial specimens, and whether such an approach is feasible in vivo using animal models. Receive-only 2.2 mm and 0.8 mm diameter intravascular loopless CMR detectors were fabricated for a clinical 3 Tesla MR scanner, and the absolute signal-to-noise ratio determined. The detectors were applied in a two-step protocol comprised of CMR angiography to identify atherosclerotic lesions, followed by high-resolution CMR to characterize FCT, lesion size, and/or vessel wall thickness. The protocol was applied in fresh human iliac and carotid artery specimens in a human-equivalent saline bath. Mean FCT measured by 80 μm intravascular CMR was compared with histology of the same sections. In vivo studies compared aortic wall thickness and plaque size in healthy and hyperlipidemic rabbit models, with post-mortem histology. Histology confirmed plaques in human specimens, with calcifications appearing as signal voids. Mean FCT agreed with histological measurements within 13% on average (correlation coefficient, R = 0.98; Bland-Altman analysis, -1.3 ± 68.9 μm). In vivo aortic wall and plaque size measured by 80 μm intravascular CMR agreed with histology. Intravascular 3T CMR with loopless detectors can both locate atherosclerotic lesions, and accurately measure FCT at high-resolution in a strategy that appears feasible in vivo. The approach shows promise for quantifying vulnerable plaque for evaluating experimental therapies.