Identifying Patients at High Risk for Stroke Despite Anticoagulation A Comparison of Contemporary Stroke Risk Stratification Schemes in an Anticoagulated Atrial Fibrillation Cohort
Identifying Patients at High Risk for Stroke Despite Anticoagulation A Comparison of Contemporary Stroke Risk Stratification Schemes in an Anticoagulated Atrial Fibrillation Cohort
复制标题
DOI：
10.1161/strokeaha.110.590257
复制
发表时间：
2010-12-01
期刊：
影响因子：
8.3
通讯作者：
Lane, Deirdre A.
中科院分区：
文献类型：
--
作者：
Lip, Gregory Y. H.;Frison, Lars;Lane, Deirdre A.
背景和目的——房颤（AF）患者的卒中风险并不均匀，各种临床危险因素为卒中风险分层方案（RSS）的制定提供了信息。在抗凝队列中，重点应放在识别尽管抗凝治疗仍处于中风高风险的患者。 方法 - 我们在抗凝 AF 临床试验队列（n = 7329 名受试者）中研究了血栓栓塞 (TE) 风险的预测因素，并测试了该队列中当代 RSS 的预测价值：CHADS(2)，Framingham，NICE 2006，美国心脏病学会/美国心脏协会/欧洲心脏病学会2006 年心脏病学、第八届美国胸科医师学会指南和 CHA(2)DS(2)-VASc 方案。结果 - 根据多变量分析，TE 的显着预测因子是中风/TIA（风险比 [HR]，2.24；P）
Background and Purpose-The risk of stroke in patients with atrial fibrillation (AF) is not homogeneous, and various clinical risk factors have informed the development of stroke risk stratification schemes (RSS). Among anticoagulated cohorts, the emphasis should be on the identification of patients who remain at high risk for stroke despite anticoagulation.Methods-We investigated predictors of thromboembolism (TE) risk in an anticoagulated AF clinical trial cohort (n=7329 subjects) and tested the predictive value of contemporary RSS in this cohort: CHADS(2), Framingham, NICE 2006, American College of Cardiology/American Heart Association/European Society of Cardiology 2006, the 8th American College of Chest Physicians guidelines and the CHA(2)DS(2)-VASc schemes.Results-On multivariate analysis, significant predictors of TE were stroke/TIA (hazard ratio [HR], 2.24; P