Microvasculature of the anterior optic nerve.
Microvasculature of the anterior optic nerve.
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DOI：
10.1016/0039-6257(94)90054-x
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发表时间：
1994-05-01
影响因子：
5.1
通讯作者：
Van Buskirk, E M
中科院分区：
文献类型：
--
作者：
Cioffi, G A;Van Buskirk, E M
青光眼的传统定义是一种眼内压升高（IOP）的疾病，这过于简单化了临床情况。一些青光眼患者的眼压从未高于正常水平，而另一些患者尽管眼压已最大限度降低，但仍继续出现视神经损伤。青光眼病因的另一个可能因素可能是前视神经区域微血管的调节。相信微血管因素很重要的原因之一是许多微血管疾病与青光眼性视神经病变有关。在这项研究中，内皮素-1 用于在玻璃体内和神经周围递送后产生眼血管系统的血管收缩。对六只兔子进行玻璃体内注射（1.25 和 2.50 微克）以评估后段的血管反应。此外，用渗透压驱动的微型泵系统将内皮素（0.0-4.2微克）输送到六只兔子的神经周围区域。两种内皮素递送方法均观察到前视神经脉管系统的血管收缩。需要更好地了解前视神经的微血管系统，以评估其与青光眼损伤的关系。使用模拟自动调节控制的药物调节这种血管供应，可能会建立血管舒缩控制的部位，并在未来控制它们的状态。
The traditional definition of glaucoma as a disorder of increased intraocular pressure (IOP) oversimplifies the clinical situation. Some glaucoma patients never have higher than normal IOP and others continue to develop optic nerve damage despite maximal lowering of IOP. Another possible factor in the etiology of glaucoma may be regulation of the regional microvasculature of the anterior optic nerve. One reason to believe that microvascular factors are important is that many microvascular diseases are associated with glaucomatous optic neuropathy. In this study, endothelin-1 was used to produce vasoconstriction of the ocular vasculature following both intravitreal and perineural delivery. Intravitreal injections (1.25 and 2.50 micrograms) were given to six rabbits to assess the vascular response of the posterior segment. In addition, endothelin (0.0-4.2 micrograms) was delivered with an osmotically driven minipump system to the perineural region of six rabbits. Vasoconstriction of the anterior optic nerve vasculature was observed following both methods of endothelin delivery. A better understanding of the microvasculature of the anterior optic nerve is needed to evaluate its relationship to glaucomatous damage. Modulation of this vascular supply, with agents that mimic autoregulatory controls, may allow the sites of vasomotor control to be established and, in the future, their status to be manipulated.