Structure and control release of chitosan/carboxymethyl cellulose microcapsules
Structure and control release of chitosan/carboxymethyl cellulose microcapsules
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DOI：
10.1002/app.1886
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发表时间：
2001-10
影响因子：
3
通讯作者：
Lina Zhang;Yong Jin;Hai-qing Liu;Yumin Du
中科院分区：
文献类型：
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作者：
Lina Zhang;Yong Jin;Hai-qing Liu;Yumin Du
采用模拟相分离的方法成功制备了壳聚糖/羧甲基纤维素钠（NaCMC）微胶囊。利用红外光谱（IR）、扫描电镜（SEM）和x射线衍射对其结构和形态进行了表征。将牛血清白蛋白（BSA）包封在微胶囊中，测试其释放行为。考察了不同壳聚糖含量和pH条件下微胶囊的溶胀行为、包封效率和释放行为。结果表明，该微胶囊包封效率高（75%），尺寸适中（20 ~ 50 μm）。微胶囊中的牛血清白蛋白在pH值为7.2时，即在肠液中迅速释放。壳聚糖含量从17%增加到38%，微胶囊中BSA的释放量减少。酸处理的微胶囊结构紧凑，由于壳聚糖的-NH2基团和CMC的-COOH基团产生强烈的静电相互作用，在pH为1.0时，即胃液中，被包被的牛血清白蛋白几乎不释放。©2001 John Wiley & Sons, Inc应用化学学报，32 (2):584-592,2001
Microcapsules of chitosan/sodium carboxymethyl cellulose (NaCMC) were successfully prepared using a novel method of emulation phase separation. Their structure and morphology were characterized by infrared spectroscopy (IR), scanning electron microscopy (SEM), and X-ray diffraction. Bovine serum albumin (BSA) was encapsulated in the microcapsules to test their release behavior. The swelling behavior, encapsulation efficiency, and release behavior of the microcapsules with different chitosan contents and pH conditions were investigated. The results indicated that the microcapsules have a high encapsulation efficiency (75%) and a suitable size (20–50 μm). The BSA in the microcapsules was speedily released at pH 7.2, namely, in intestinal fluid. The BSA release was reduced with increase of the chitosan content from 17 to 38% in the microcapsules. Acid-treated microcapsules have a compact structure, owing to a strong electrostatic interaction caused by —NH2 groups of chitosan and —COOH groups of CMC, and the encapsulated BSA was hardly released at pH 1.0, namely, in gastric juice. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 584–592, 2001