Synthesis of Notoamide J: A Potentially Pivotal Intermediate in the Biosynthesis of Several Prenylated Indole Alkaloids
Synthesis of Notoamide J: A Potentially Pivotal Intermediate in the Biosynthesis of Several Prenylated Indole Alkaloids
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DOI：
10.1021/jo100332c
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发表时间：
2010-05-07
影响因子：
3.6
通讯作者：
Williams, Robert M.
中科院分区：
文献类型：
--
作者：
Finefield, Jennifer M.;Williams, Robert M.
本文描述了诺托酰胺 J（一种新的异戊二烯化吲哚生物碱和潜在的生物合成前体）的有效全合成。该合成从 L-脯氨酸和取代的色氨酸衍生物开始，在最后一步中还采用氧化和频哪醇重排来形成羟吲哚。
An efficient total synthesis of notoamide J, a new prenylated indole alkaloid and potential biosynthetic precursor, is described herein. Starting from L-proline and a substituted tryptophan derivative, this synthesis also employs an oxidation and pinacol rearrangement for the formation of the oxindole in the final step.