Study of Embryotoxicity of Commercial Dental Gold-silver-palladium Alloy by Corrosion using Acid and Artificial Saliva
Study of Embryotoxicity of Commercial Dental Gold-silver-palladium Alloy by Corrosion using Acid and Artificial Saliva
复制标题
商业牙科金银钯合金酸和人工唾液腐蚀的胚胎毒性研究
DOI：
10.11223/jarde.13.77
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Suese K.
中科院分区：
文献类型：
--
作者：
Imai K;Nishitani Y;Hoshika T;Akiyama M;Morita S;Iseki T;Yoshida H;Matsumoto K;Tamura I;Shida M;Sawai H;Ohkubo T;Suese K.
为了研制具有高度生物安全性的牙科金银钯合金组合物，用防水砂纸刮擦2种商用合金表面，用盐酸、硫酸和人工唾液腐蚀，并对腐蚀产物的胚胎毒性进行了研究。通过胚胎干细胞试验(EST)中小鼠ES-D3细胞对小鼠心肌细胞的分化率和碱性磷酸酶(ALP)活性来评价胚胎毒性。与无表面腐蚀的阴性对照相比，细胞分化率略有下降。ALP活性测定结果相似。
To develop highly biologically safe dental gold-silver-palladium alloy compositions, the surfaces of 2 commercially available alloys were scraped with waterproof abrasive paper and corroded with hydrochloric acid, sulfuric acid, and artificial saliva, and the embryotoxicity of the corroded products was investigated. The embryotoxicity was evaluated based on the rate of differentiation of mouse ES-D3 cells to the mouse myocardial cells used in Embryo Stem Cell Test (EST) protocol and alkaline phosphatase (ALP) activity. Compared with that of the negative control without surface corrosion, the cell differentiation rate slightly decreased. The results of ALP activity were similar.