Acute effects of ambient particulate matter on blood pressure: differential effects across urban communities.
Acute effects of ambient particulate matter on blood pressure: differential effects across urban communities.
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DOI：
10.1161/hypertensionaha.108.123877
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Brook RD
中科院分区：
文献类型：
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作者：
Dvonch JT;Kannan S;Schulz AJ;Keeler GJ;Mentz G;House J;Benjamin A;Max P;Bard RL;Brook RD
最近的研究表明，暴露于直径<2.5μm的环境颗粒物（PM2.5）与不良心血管结局之间存在联系。本研究的目的是研究不同社区水平PM2.5暴露对成年人群每日血压（BP）测量的影响。在2002年5月至2003年4月期间，对居住在密歇根州底特律三个不同社区的347名成年人在两个时间点进行了血压检查。在此期间，评估了每个社区的PM2.5暴露情况，以及PM2.5与血压之间的多变量关联。在结合所有三个社区的模型中，PM2.5与收缩压（SP）显著相关；每日PM2.5增加10 μg/m3与SP增加3.2 mm Hg相关（p=0.05）。然而，在增加位置相互作用的模型中，在PM2.5水平最高的社区内观察到SP的影响更大；PM2.5日升高10 μg/m3， SP升高8.6 mm Hg （p=0.01）。我们还发现，年轻（<55岁）和未服用降压药物是血压升高的重要预测因素。在服用降压药物的参与者中，PM2.5对血压的影响似乎有所减轻，这在一定程度上解释了年龄的影响，因为55岁以下的参与者服用降压药物的可能性较小。暴露于环境PM2.5的短期增加与成人急性血压升高有关，特别是在暴露水平较高的社区。
Recent studies have suggested a link between exposure to ambient particulate matter <2.5μm in diameter (PM2.5) and adverse cardiovascular outcomes. The objective of this study was to examine the effects of differing community-level exposure to PM2.5 on daily measures of blood pressure (BP) among an adult population. During the period May 2002 through April 2003, BP was examined at two time points for 347 adults residing in three distinct communities of Detroit, MI. Exposure to PM2.5 was assessed in each community during this period, along with multivariate associations between PM2.5 and BP. In models combining all three communities, PM2.5 was significantly associated with systolic pressure (SP); a 10 μg/m3 increase in daily PM2.5 was associated with a 3.2 mm Hg increase in SP (p=0.05). However, in models that added a location interaction, larger effects were observed for SP within the community with highest PM2.5 levels; a 10 μg/m3 increase in daily PM2.5 was associated with a 8.6 mm Hg increase in SP (p=0.01). We also found young age (<55 years) and not taking BP medications to be significant predictors of increased BP effects. Among those taking BP medications, the PM2.5 effect on BP appeared to be mitigated, partially explaining the age effect, as those participants less than 55 years were less likely to take BP medications. Short-term increases in exposure to ambient PM2.5 are associated with acute increases in BP in adults, especially within communities with elevated levels of exposure.