Effect of Starting Penile Rehabilitation with Sildenafil Immediately after Robot-Assisted Laparoscopic Radical Prostatectomy on Erectile Function Recovery: A Prospective Randomized Trial
Effect of Starting Penile Rehabilitation with Sildenafil Immediately after Robot-Assisted Laparoscopic Radical Prostatectomy on Erectile Function Recovery: A Prospective Randomized Trial
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DOI：
10.1016/j.juro.2017.12.060
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发表时间：
2018-06-01
影响因子：
6.6
通讯作者：
Lee, Sang Eun
中科院分区：
文献类型：
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作者：
Jo, Jung Ki;Jeong, Seong Jin;Lee, Sang Eun
目的：在根治性前列腺切除术后立即开始使用磷酸二酯酶5型抑制剂进行早期康复治疗是否比延迟使用相同方案的治疗更有效地改善勃起功能恢复，在实际实践中尚未得到明确证明。我们进行了一项前瞻性随机试验来确定这一点。材料与方法：将IIEF-5（国际勃起功能指数-5）术前评分在17分及以上的前列腺癌患者随机分为两组：早期组为拔除尿道后立即服用西地那非100mg，每周2次，连续3个月；延迟组为保留神经的机器人辅助腹腔镜根治性前列腺切除术后仅3个月。研究的主要终点是12个月内勃起功能完全恢复率，定义为IIEF-5评分为17分或更高。结果：在120例随机分组的患者中，早期组在12个月内完全康复的比例明显高于延迟组(β = 0.356, p
Purpose: It has not been clearly proved in real practice whether early rehabilitation with phosphodiesterase type 5 inhibitors starting immediately after radical prostatectomy improves erectile function recovery more effectively than delayed treatment with the same regimen. We performed a prospective randomized trial to identify this.Materials and Methods: Patients with prostate cancer and an IIEF-5 (International Index of Erectile Function-5) preoperative score of 17 or greater were randomly assigned to receive sildenafil 100 mg regularly twice per week for 3 months immediately after urethral catheter removal as the early group or only 3 months after nerve sparing robot-assisted laparoscopic radical prostatectomy as the delayed group. The study primary end point was the full erectile function recovery rate, defined as an IIEF-5 score of 17 or greater, during the 12 months.Results: Of the 120 randomized patients the proportion who achieved full recovery was significantly higher during the 12 months in the early group than in the delayed group (beta = 0.356, p