The Heterochronic Gene lin-14 Controls Axonal Degeneration in C. elegans Neurons.
The Heterochronic Gene lin-14 Controls Axonal Degeneration in C. elegans Neurons.
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异时基因 lin-14 控制线虫神经元的轴突变性。
DOI：
10.1016/j.celrep.2017.08.083
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发表时间：
2017
期刊：
影响因子：
8.8
通讯作者：
Hilliard,MassimoA
中科院分区：
文献类型：
--
作者：
Ritchie,FionaK;Knable,Rhianna;Chaplin,Justin;Gursanscky,Rhiannon;Gallegos,Maria;Neumann,Brent;Hilliard,MassimoA
轴突的不成比例的长度使其结构和功能的维护成为神经元的主要任务。异时Genelin-14以前被认为参与调节线虫中关键发育事件的时间。在这里，我们报告LIN-14对于维持神经元的完整性是至关重要的。缺乏lin-14的动物在感觉神经元和运动神经元上都表现出轴突退化和指导错误。我们证明了LIN-14在神经元内的自主细胞功能和在周围组织中的非细胞自主功能，我们还证明了轴突与其周围组织之间的相互作用对于轴突结构的保存是必不可少的。此外，我们证明，为了促进动物一生中轴突的维持，只有在发育早期的很短时期内才需要lin-14的表达。我们的结果确定了LIN-14在防止轴突退化和维持轴突与其周围组织之间的正确相互作用方面的关键作用。
The disproportionate length of an axon makes its structural and functional maintenance a major task for a neuron. The heterochronic genelin-14has previously been implicated in regulating the timing of key developmental events in the nematodeC. elegans. Here, we report that LIN-14 is critical for maintaining neuronal integrity. Animals lackinglin-14display axonal degeneration and guidance errors in both sensory and motor neurons. We demonstrate that LIN-14 functions both cell autonomously within the neuron and non-cell autonomously in the surrounding tissue, and we show that interaction between the axon and its surrounding tissue is essential for the preservation of axonal structure. Furthermore, we demonstrate thatlin-14expression is only required during a short period early in development in order to promote axonal maintenance throughout the animal's life. Our results identify a crucial role for LIN-14 in preventing axonal degeneration and in maintaining correct interaction between an axon and its surrounding tissue.