Effects of Prenatal Stress on Formalin-Induced Acute and Persistent Pain in Adult Male Rats
Effects of Prenatal Stress on Formalin-Induced Acute and Persistent Pain in Adult Male Rats
复制标题
产前应激对成年雄性大鼠福尔马林引起的急性和持续性疼痛的影响
DOI：
--
复制
发表时间：
2002
影响因子：
0.7
通讯作者：
I. Butkevich
中科院分区：
文献类型：
--
作者：
I. Butkevich
用福尔马林实验研究了妊娠最后一周暴露于束缚应激的90d龄雌性Wistar大鼠的行为反应。特异性双相行为反应以急性(第1期)和持续性紧张性疼痛(第2期)为特征。在胎儿期应激大鼠，伤害性反应的强度(通过屈曲+抖动的次数和舔爪的持续时间来评价)只在第二阶段发生变化。在间期，屈曲+抖动模式(而不是舔舔模式)对伤害性刺激的反应是易化的。第一阶段的反应强度和两个阶段的持续时间保持不变。我们的发现表明，产前应激调节90天大的后代的伤害性敏感性：它影响紧张性(炎症)的持续时间，但不影响急性疼痛的持续时间。结论：胎儿期应激对福尔马林试验中急性疼痛和持续性疼痛的影响机制不同。
Behavioral responses of 90-day-old male offspring from female Wistar rats exposed to restraint stress during the last week of pregnancy were studied in the formalin test. Specific biphasic behavioral response characterized acute (phase 1) and persistent tonic pain (phase 2). The intensity of nociceptive responses (evaluated by the number of flexions+ shakings and by the duration of paw licking) in prenatally stressed rats changed only during phase 2. During interphase, facilitation of the flexion+shakings pattern (but not the licking pattern) in response to nociceptive stimulation was seen. The response intensity during phase 1 and the duration of both phases remained unchanged. Our findings suggest that prenatal stress modulates nociceptive sensitivity in 90-day-old offspring: it affects the duration of tonic (inflammatory), but not of acute pain. It is concluded that different mechanisms are responsible for the effects of prenatal stress on acute and persistent pain in the formalin test.