Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imaging
Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imaging
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DOI：
10.1002/mrm.20705
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发表时间：
2005-12-01
影响因子：
3.3
通讯作者：
Helpern, JA
中科院分区：
文献类型：
--
作者：
Lu, HZ;Law, M;Helpern, JA
脑血容量(CBV)的定量测定对了解脑生理和病理生理学具有重要意义。在这项工作中，提出了一种新的方法来准确测量绝对CBV(ACBV)，使用血管-空间-占用(VASO)MRI，一个血液清零脉冲序列，结合Gd-DTPA的T缩短特性。在注射造影剂之前和之后，采集具有相同成像参数的两个VASO图像，产生反映大脑中存在的血液量的减影图像，即CBV。有了额外的归一化因子，就可以估计出每100毫升大脑中血液的CBV单位。在1.5T和3T系统上的实验结果表明，可以获得高空间分辨率的aCBV图，并且具有很高的重复性。灰质和白质的平均aCBV值分别为5.5+/-0.2和1.4+/-0.1毫升血液/100毫升脑。与动态磁化率对比技术相比，VASO IVIRI基于相对简单的理论，计算CBV不需要测量动脉输入功能。与以往的增强前后差异方法相比，Vaso MRI提供了增强前后的最大信号差异，并且不需要使用全血进行信号归一化。《医学杂志》54：1403-1411,2005。(C)2005年Wiley-Liss，Inc.
Quantitative determination of cerebral blood volume (CBV) is important for understanding brain physiology and pathophysiology. In this work, a novel approach is presented for accurate measurement of absolute CBV (aCBV) using vascular-space-occupancy (VASO) MRI, a blood-nulling pulse sequence, in combination with the T, shortening property of Gd-DTPA. Two VASO images with identical imaging parameters are acquired before and after contrast agent injection, resulting in a subtracted image that reflects the amount of blood present in the brain, i.e., CBV. With an additional normalizing factor, aCBV in units of milliliters of blood per 100 mL of brain can be estimated. Experimental results at 1.5 and 3 T systems showed that aCBV maps with high spatial resolution can be obtained with high reproducibility. The averaged aCBV values in gray and white matter were 5.5 +/- 0.2 and 1.4 +/- 0.1 mL of blood/100 mL of brain, respectively. Compared to dynamic susceptibility contrast techniques, VASO IVIRI is based upon a relatively straightforward theory and the calculation of CBV does not require measurement of an arterial input function. In comparison with previous pre/postcontrast difference approaches, VASO MRI provides maximal signal difference between pre- and postcontrast situation and does not require the use of whole blood for signal normalization. Magn Reson Med 54:1403-1411, 2005. (c) 2005 Wiley-Liss, Inc.