Stem and progenitor cells: advancing bone tissue engineering.
Stem and progenitor cells: advancing bone tissue engineering.
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DOI：
10.1007/s13346-015-0235-1
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发表时间：
2016-04
影响因子：
5.4
通讯作者：
Longaker MT
中科院分区：
文献类型：
--
作者：
Tevlin R;Walmsley GG;Marecic O;Hu MS;Wan DC;Longaker MT
与许多其他出生后组织不同，骨骼可以再生和自我修复;然而，这种能力可以克服。传统上，外科重建策略已实施自体，同种异体和假体材料。自体骨是最好的选择，但供应有限，而且还需要额外的外科手术。在再生组织工程中，在创建功能性可植入替代组织时需要考虑无数问题。重要的是，必须存在容易获得的、丰富的细胞来源，其具有表达所需组织的表型的能力，以及生物相容性支架，以将细胞递送至受损区域。使用PubMed进行文献综述;筛选同行评审出版物的相关性，以确定干细胞和祖细胞对骨组织工程领域的贡献的关键进展。本文简要介绍了用于骨组织工程的各种成体干细胞，如间充质干细胞（包括骨髓和脂肪源性干细胞）、内皮祖细胞和诱导多能干细胞。然后，我们讨论了与其应用相关的许多进展，并随后重点关注该领域的技术进步，然后讨论目前在临床实践中使用的关键再生策略。干细胞和祖细胞在骨组织工程策略中的应用能够对再生医学产生重大影响，并降低患者的发病率。随着再生医学领域致力于利用人体自身的细胞进行治疗，科学创新在过去十年中导致了基于干细胞的疗法的巨大进步。
Unlike many other postnatal tissues, bone can regenerate and repair itself; nevertheless, this capacity can be overcome. Traditionally, surgical reconstructive strategies have implemented autologous, allogeneic and prosthetic materials. Autologous bone—the best option—is limited in supply, and also mandates an additional surgical procedure. In regenerative tissue engineering, there are myriad issues to consider in the creation of a functional, implantable replacement tissue. Importantly, there must exist an easily accessible, abundant cell source with the capacity to express the phenotype of the desired tissue, and a biocompatible scaffold to deliver the cells to the damaged region. A literature review was performed using PubMed; peer-reviewed publications were screened for relevance in order to identify key advances in stem and progenitor cell contribution to the field of bone tissue engineering. In this review, we briefly introduce various adult stem cells implemented in bone tissue engineering such as mesenchymal stem cells (including bone marrow- and adipose-derived stem cells), endothelial progenitor cells and induced pluripotent stem cells. We then discuss numerous advances associated with their application and subsequently focus on technological advances in the field, before addressing key regenerative strategies currently used in clinical practice. Stem and progenitor cell implementation in bone tissue engineering strategies have the ability to make a major impact on regenerative medicine and reduce patient morbidity. As the field of regenerative medicine endeavors to harness the body's own cells for treatment, scientific innovation has led to great advances in stem cell based therapies in the past decade.