No evidence of association between habitual physical activity and ECG traits: Insights from the electronic Framingham Heart Study.
No evidence of association between habitual physical activity and ECG traits: Insights from the electronic Framingham Heart Study.
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DOI：
10.1016/j.cvdhj.2021.11.004
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发表时间：
2022-03
影响因子：
--
通讯作者：
Lin H
中科院分区：
文献类型：
--
作者：
Kornej J;Murabito JM;Zhang Y;Liu C;Trinquart L;Sardana M;Manders ES;Hammond MM;Spartano NL;Pathiravasan CH;Wang X;Borrelli B;McManus DD;Benjamin EJ;Lin H
体力活动（PA）可改善与心血管疾病（高血压、糖尿病、肥胖）相关的风险因素，并降低心力衰竭、中风和冠心病的风险。1智能手表是监测习惯性PA的有用工具，可以增强社区居民个体的表型。智能手表报告的每日步数提供了一个有用的测量整体PA捕获各种运动类型。心电图（ECG）特征已被确立为心血管风险标志物，但关于习惯性PA与ECG特征的相关性的知识有限。心电图特征如PR间期、QRS和QT间期可用于诊断传导障碍和预测心血管疾病，包括心源性猝死、心肌梗死、心力衰竭和房颤。已知低PA与心血管健康不良有关。因此，我们假设ECG性状可能作为PA和心血管健康之间的中间表型。具体而言，我们假设较高的平均PR间期、QRS和QTc间期与较低的PA相关。当前分析的目的是检查电子心脏研究（eFHS）参与者的智能手表平均每日步数与ECG特征之间的关联。Frachial Heart研究（FHS）是一项位于马萨诸塞州Frachial的观察性多代队列研究。eFHS队列于2016年6月在第三次研究中心检查期间开始招募来自第三代队列、多种族Omni 2和新后代配偶队列的受试者。2如果参与者拥有兼容iOS（版本9或更高）的iPhone，则将Apple Watch作为eFHS的一部分提供给他们。参与者还可以佩戴自己的Apple Watch。截至2019年1月31日，1948名受试者入组，至少随访12个月。所有参与者都接受了ECG检查，作为其检查的常规部分。在FHS研究中心的检查期间还测量了临床变量。HabitantPA测量为平均值，
Physical activity (PA) improves risk factors associated with cardiovascular disease (high blood pressure, diabetes, obesity) and reduces the risk of heart failure, stroke, and coronary heart disease. 1 Smartwatches are useful tools for monitoring habitual PA and may enhance phenotyping of community-dwelling individuals. Daily step count reported by smartwatches offers a helpful measure of overall PA capturing a variety of exercise types. Electrocardiogram (ECG) traits are established cardiovascular risk markers, but limited knowledge is available regarding the association of habitual PA with ECG traits. ECG traits such as PR interval, QRS, and QT interval can be used to diagnose conduction disturbances and to predict cardiovascular diseases including sudden cardiac death, myocardial infarction, heart failure, and atrial fibrillation. Low PA is known to associate with poor cardiovascular health. We therefore hypothesized that ECG traits might act as an intermediate phenotype between PA and cardiovascular health. Specifically, we hypothesized that higher mean PR interval, QRS, and QTc interval would be associated with lower PA. The objective of the current analysis was to examine associations between average daily steps from the smartwatch and ECG traits among the electronic Framingham Heart Study (eFHS) participants. The Framingham Heart Study (FHS) is an observational multigenerational cohort located in Framingham, Massachusetts. The eFHS cohort started enrolling participants from the Third Generation Cohort, multiethnic Omni 2, and New Offspring Spouse Cohort in June 2016 during their third research center examination. 2 The Apple Watch was provided to participants as part of the eFHS if they owned an iPhone with a compatible iOS (version 9 or higher). Participants were also allowed to wear their own Apple Watch. Up to January 31, 2019, 1948 participants were enrolled with at least 12-month follow-up period. All participants underwent an ECG as a routine part of their examination. Clinical variables were also measured during the examination at the FHS Research Center. Habitual PA was measured as the average
影响因子：
24
作者：
Soliman, Elsayed Z.;Howard, George;Cushman, Mary;Kissela, Brett;Kleindorfer, Dawn;Le, Anh;Judd, Suzanne;McClure, Leslie A.;Howard, Virginia J.
通讯作者：
Howard, Virginia J.
影响因子：
3.3
作者：
Michishita, Ryoma;Fukae, Chika;Kiyonaga, Akira
通讯作者：
Kiyonaga, Akira
影响因子：
7.4
作者：
McManus, David D.;Trinquart, Ludovic;Murabito, Joanne M.
通讯作者：
Murabito, Joanne M.