Omeprazole therapy and salivary flow rate in duodenal ulcer patients.
Omeprazole therapy and salivary flow rate in duodenal ulcer patients.
复制标题
十二指肠溃疡患者的奥美拉唑治疗和唾液流量。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
J. Górski
中科院分区：
文献类型：
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作者：
Z. Namiot;J. Stasiewicz;M. Kralisz;M. Kozuszyńska;Adam R Markowski;F. K. Aljanaby;A. Kemona;J. Górski
背景
以前的报告表明，在一些反流性食管炎患者奥美拉唑治疗改变唾液分泌。这项研究的目的是检查十二指肠溃疡患者的这种影响。
材料和方法
本研究招募了39名幽门螺杆菌阳性受试者，男女均为，主要为男性。他们仅服用奥美拉唑（n = 17），或奥美拉唑与阿莫西林或阿莫西林和替硝唑（n = 22）联合用药两周。在基础条件下和胃分泌试验期间，在给药前和给药结束时评估唾液分泌。同时监测胃分泌和唾液流速。此外，还对胃炎评分和血清胃泌素水平进行了评估。
结果
奥美拉唑单药治疗患者的基础唾液分泌保持不变，但根除方案患者的8个唾液收集期中有5个唾液分泌减少。在胃分泌试验期间，两组的唾液分泌物均下降，但仅在五肽胃泌素刺激后（奥美拉唑组患者在一个采集期内，根除治疗组患者在三个采集期内）。观察到的唾液分泌变化与给药前胃pH值呈负相关。
结论
奥美拉唑和基于奥美拉唑的根除治疗对唾液流速的影响可能继发于胃pH值的变化，并且可能与食管-唾液反射的产生有关。
BACKGROUND
Previous reports have shown that in some reflux-oesophagitis patients omeprazole therapy alters salivary secretion. The aim of the study was to examine this effect in duodenal ulcer patients.
MATERIAL AND METHODS
Thirty nine Helicobacter pylori positive subjects of both sexes, predominantly men, were recruited for the study. They were taking for two weeks only omeprazole (n = 17), or omeprazole in combination with either amoxycillin or amoxycillin and tinidazole (n = 22). Salivary secretion was assessed before and at the end of the treatment, both in basal conditions and during a gastric secretory test. Gastric secretion was monitored concurrently with salivary flow rate. Additionally gastritis score and serum gastrin levels were assessed.
RESULTS
Basal salivary secretions remained unchanged in patients on omeprazole monotherapy, but decreased in five of eight saliva collection periods in patients on eradication regimens. During the gastric secretory test, salivary secretions fell in both groups, but only after pentagastrin stimulation (in one collection period in patients on omeprazole, and in three collection periods in patients on eradication therapy). The observed changes in salivary secretion were inversely related to the pre-treatment gastric pH values.
CONCLUSION
The influence of omeprazole and omeprazole-based eradication therapies on salivary flow rate is presumably secondary to changes in gastric pH values and is likely to be related to oesophago-salivary reflex generation.