Glutamate Signaling in the Auditory Brainstem
Glutamate Signaling in the Auditory Brainstem
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DOI：
10.1007/978-3-319-21530-3_4
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Lu, Yong
中科院分区：
文献类型：
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作者：
Sanchez, Jason Tait;Lu, Yong
听性脑干中谷氨酸信号传导是一个动态过程。它涉及突触前和突触后因素的完美协调，这些因素可靠地允许神经元之间的信息传递。与其他大脑区域相比，听觉脑干中的谷氨酸信号传导是独特的，因为它提供了感知行为相关通信信号的初始机制。这种机制的破坏被认为是几种听力相关疾病的基础。本章以埃德温·鲁贝尔博士及其同事的工作为基础，从概念上概述了调节听觉脑干中谷氨酸信号传导的因素，以及负责发育、活动依赖性调节、病理生理学和神经调节的决定因素。
Glutamate signaling in the auditory brainstem is a dynamic process. It involves the perfect coordination of pre- and postsynaptic factors that reliably permit the transfer of information between neurons. When compared to other brain regions, glutamate signaling in the auditory brainstem is unique in that it provides the initial mechanisms underlying the perception of behaviorally relevant communication signals. Disruptions in such mechanisms are thought to underlie several hearing-related disorders. Relying on the foundation of work by Dr. Edwin Rubel and colleagues, this chapter offers a conceptual overview of factors that regulate glutamate signaling in the auditory brainstem, as well as determinants responsible for development, activity-dependent regulation, pathophysiology, and neuromodulation.