NONUNIFORM PROBABILITY OF GLUTAMATE RELEASE AT A HIPPOCAMPAL SYNAPSE
NONUNIFORM PROBABILITY OF GLUTAMATE RELEASE AT A HIPPOCAMPAL SYNAPSE
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DOI：
10.1126/science.7901909
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发表时间：
1993-10-29
期刊：
影响因子：
56.9
通讯作者：
WESTBROOK, GL
中科院分区：
文献类型：
--
作者：
ROSENMUND, C;CLEMENTS, JD;WESTBROOK, GL
神经递质释放概率（P（r））的变化是突触可塑性的重要机制。虽然P（r）通常被认为是相同的所有终端在一个单一的突触，这一假设是难以调和的不均匀的大小和结构的突触终端在中枢神经系统。通过分析不可逆开放通道阻滞剂MK-801对N-甲基-D-天冬氨酸受体介导的突触电流的进行性阻滞，在培养的海马神经元上的兴奋性突触处测量释放概率。释放概率是不均匀的（范围为0.09至0.54）终端所产生的一个单一的轴突，其中大部分有一个低P（r）。然而，具有高P（r）的终端更可能受到长时程增强中发生的活动依赖性调制的影响。
A change in the probability of neurotransmitter release (P(r)) is an important mechanism underlying synaptic plasticity. Although P(r) is often assumed to be the same for all terminals at a single synapse, this assumption is difficult to reconcile with the nonuniform size and structure of synaptic terminals in the central nervous system. Release probability was measured at excitatory synapses on cultured hippocampal neurons by analysis of the progressive block of N-methyl-D-aspartate receptor-mediated synaptic currents by the irreversible open channel blocker MK-801. Release probability was nonuniform (range of 0.09 to 0.54) for terminals arising from a single axon, the majority of which had a low P(r). However, terminals with high P(r) are more likely to be affected by the activity-dependent modulation that occurs in long-term potentiation.