Widely Applicable Deprotection Method of 2,2,2-Trichloroethoxycarbonyl (Troc) Group Using Tetrabutylammonium Fluoride
Widely Applicable Deprotection Method of 2,2,2-Trichloroethoxycarbonyl (Troc) Group Using Tetrabutylammonium Fluoride
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DOI：
10.1080/07328303.2010.512405
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发表时间：
2010-01-01
影响因子：
1
通讯作者：
Fukase, Koichi
中科院分区：
文献类型：
--
作者：
Huang, Cheng-yuan;Wang, Ning;Fukase, Koichi
在温和的条件下，用四丁基氟化铵(TBAF)处理氨基葡萄糖和胞浆酸衍生物中的N-Troc(2，2，2-三氯乙氧羰基)基团。对氨基葡萄糖等氨基糖中氨基的Troc保护的使用增加了选择性和高效糖基化的重要性，这里描述的裂解方法将扩大在制备各种糖聚糖中使用Troc基团的可用机会。这种裂解对于不稳定的化合物或可能在酸性、强碱性或还原条件下分解的化合物特别有利。
The N-Troc (2,2,2-trichloroethoxycarbonyl) groups in glucosamine and muramic acid derivatives were removed by treatment with tetrabutylammonium fluoride (TBAF) under mild conditions. The use of Troc protection for the amino group in aminosugars such as glucosamine is increasing the importance for selective and efficient glycosylation, and the cleavage method described here will expand the available opportunities for using the Troc group in the preparation of a variety of glycans. This cleavage is especially advantageous for compounds that are labile or may be decomposed under acidic conditions, strong basic conditions, or reductive conditions.