Myoendothelial contacts in glomerular arterioles and in renal interlobular arteries of rat, mouse and Tupaia belangeri
Myoendothelial contacts in glomerular arterioles and in renal interlobular arteries of rat, mouse and Tupaia belangeri
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DOI：
10.1007/bf00217856
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发表时间：
2004
影响因子：
3.6
通讯作者：
R. Taugner;H. Kirchheim;W. Forssmann
中科院分区：
文献类型：
--
作者：
R. Taugner;H. Kirchheim;W. Forssmann
在大鼠和小鼠肾脏的薄切片中，对肾小球小动脉的传入和传出以及小叶间动脉中的图尼卡中膜和内膜的细胞接触进行了研究和半定量评价。在传入小动脉（包括肾小球部分）中，内皮细胞和平滑肌细胞之间以及内皮细胞和颗粒（产生肾素）细胞之间存在接触。这些肌肉内皮细胞接触的形式从胞体和细胞突起的简单并置到内皮细胞进入中膜细胞（常见）或中膜细胞进入内皮细胞（罕见）的广泛的棒状凹陷。大多数这些细胞接触似乎包含肌内皮缝隙连接。在大鼠和小鼠的小叶间动脉中发现的肌内皮接触比其传入小动脉中的少，大多数为棒状。简单的膜沉积占主导地位的众多的肌内皮接触的传出小动脉。在树鼩的肾脏中也获得了类似的结果（未经定量分析）。肌内皮接触可能允许机械（自动调节）和体液刺激的检测和传播。
Cell contacts between elements of the tunica media and the intima in the afferent and efferent glomerular arteriole and in the interlobular artery were studied and evaluated semiquantitatively in thin sections of rat and mouse kidney.In the afferent arterioles, including their juxtaglomerular portion, contacts were seen between endothelial and smooth muscle cells, and between endothelial and granulated (renin producing) cells. The form of these musculoendothelial contacts varied from simple appositions of perikarya and cell processes to extensive club-shaped indentations of endothelial cells into media cells (common) or media cells into endothelial cells (rare). Most of these cell contacts seem to contain myoendothelial gap junctions. Fewer, mostly club-shaped myoendothelial contacts were found in the interlobular arteries of rats and mice than in their afferent arterioles. Simple membrane appositions predominated among the numerous myoendothelial contacts of efferent arterioles. Similar results (without quantitative analysis) were obtained in the kidney ofTupaia belangeri.The myoendothelial contacts may allow the detection and propagation of mechanical (autoregulatory) and humoral stimuli.