Chemically Cross-Linked Chitin Nanocrystal Scaffolds for Drug Delivery
Chemically Cross-Linked Chitin Nanocrystal Scaffolds for Drug Delivery
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DOI：
10.1021/acsanm.8b01585
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发表时间：
2018-11
影响因子：
5.9
通讯作者：
Xianfeng Ou;Jingqi Zheng;Xiujuan Zhao;Mingxian Liu
中科院分区：
文献类型：
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作者：
Xianfeng Ou;Jingqi Zheng;Xiujuan Zhao;Mingxian Liu
甲壳素纳米晶（ChNCs）是由甲壳素酸水解制备的，具有均一的针状形貌和良好的分散稳定性，是一种理想的药物载体。从不同浓度的ChNC分散体中冻干多孔ChNC支架，然后通过与戊二醛的反应交联。采用扫描电子显微镜、傅里叶变换红外光谱、X射线衍射、热重分析、力学性能、孔隙率和溶胀性能测试等技术对化学交联甲壳素纳米纤维（XChNC）支架的结构进行了表征。XChNC支架的压缩机械强度、密度、孔隙率和吸水率取决于ChNC的浓度。XChNC支架显示出平均孔径为1.65 μm的互连孔。以姜黄素为模型药物，通过吐温20小鼠包封法将姜黄素负载到XChNC支架中。
Chitin nanocrystals (ChNCs), prepared by acid hydrolysis of chitin, exhibit a uniform needlelike morphology and high dispersion stability in aqueous solutions, which makes them good candidates for drug delivery. Porous ChNC scaffolds were freeze-dried from different concentrations of ChNC dispersions and then cross-linked by a reaction with glutaraldehyde. Various techniques, including scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and testing of mechanical properties, porosity, and swelling properties, were used to characterize the structure of chemically cross-linked chitin nanocrystal (XChNC) scaffolds. The compressive mechanical strength, density, porosity, and water absorption rate of XChNC scaffolds were dependent on the concentration of ChNCs. XChNC scaffolds showed interconnected pores with a mean pore size of ∼65 μm diameter. Curcumin was used as a model drug and loaded into the XChNC scaffold by encapsulation in Tween 20 mice...