Polyoxometalate Modified by Zeolite Imidazole Framework for the pH-Responsive Electrodynamic/Chemodynamic Therapy
Polyoxometalate Modified by Zeolite Imidazole Framework for the pH-Responsive Electrodynamic/Chemodynamic Therapy
复制标题
沸石咪唑骨架修饰的多金属氧酸盐用于 pH 响应电动/化学动力学治疗
DOI：
10.1021/acsami.1c19985
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发表时间：
2022-01-20
影响因子：
9.5
通讯作者：
Wang, Lei
中科院分区：
文献类型：
--
作者：
Song, Yan;Sun, Yuan;Wang, Lei
电动力学疗法（EDT）和化学动力学疗法（CDT）在未来肿瘤治疗方面具有潜力；然而，由于其固有缺陷，它们的潜在应用受到极大阻碍。将EDT和CDT相结合被认为是一种能使这两种基于活性氧（ROS）的方法的优势最大化的有效途径。然而，开发具有“一体化”功能的新型纳米材料仍然是一个巨大挑战。在这项工作中，利用沸石咪唑骨架对多金属氧酸盐纳米粒子（NPs）进行修饰（POM@ZIF - 8），以便将EDT与CDT整合。所得的POM@ZIF - 8 NPs能够通过电场（E）诱导的POM NPs表面的催化反应有效地诱导活性氧物质（ROS）的产生。同时，POM@ZIF - 8 NPs可以通过类芬顿反应将细胞内的H₂O₂催化为ROS，从而实现EDT和CDT的结合。此外，由于ZIF - 8对酸有响应，它可以保护正常组织并避免副作用。值得注意的是，发现POM@ZIF - 8 + E组的细胞毒性和细胞凋亡率（80%）明显高于E组（55%）。因此，在体外和体内都可以观察到较高的肿瘤抑制现象。本研究因此为具有卓越疗效的联合治疗模式提供了一种替代概念。
Electrodynamic therapy (EDT) and chemodynamic therapy (CDT) have the potential for future tumor treatment; however, their underlying applications are greatly hindered owing to their inherent drawbacks. The combination of EDT and CDT has been considered to be an effective way to maximize the superiorities of these two ROS-based methodologies. However, the development of novel nanomaterials with "one-for-all" functions still remains a big challenge. In this work, the polyoxometalate nanoparticles (NPs) were decorated using the zeolite imidazole framework (POM@ZIF-8) in order to integrate the EDT with CDT. The resulting POM@ZIF-8 NPs can effectively induce the generation of reactive oxygen species (ROS) via a catalytic reaction on the surface of POM NPs induced by an electric field (E). At the same time, POM@ZIF-8 NPs can catalyze the intracellular H2O2 into ROS via a Fenton-like reaction, thereby achieving the combination of EDT and CDT. Besides, since ZIF-8 is acid-responsive, it can protect normal tissues and avoid side effects. Of great note is that the cytotoxicity and the apoptosis rate of the POM@ZIF-8+E group (80%) were found to be significantly higher than that of the E group (55%). As a result, a high tumor inhibition phenomenon can be observed both in vitro and in vivo. The present study thus provides an alternative concept for combinational therapeutic modality with exceptional efficacy.