Current approaches to measurement of insulin secretion.
Current approaches to measurement of insulin secretion.
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当前测量胰岛素分泌的方法。
DOI：
10.1002/dmr.5610020306
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Rubenstein,AH
中科院分区：
文献类型：
--
作者：
Polonsky,KS;Rubenstein,AH
本文综述的研究表明，C-肽和胰岛素以等摩尔浓度从β细胞共分泌，C-肽不经历显著的肝提取，并且其MCR在生理浓度范围内保持恒定。此外，C肽的外周分布动力学可以用二室数学模型描述。如果通过分析C-肽衰减曲线在个体受试者中导出模型参数，则该信息随后可用于从内源性分泌的C-肽浓度以很高的准确度导出胰岛素分泌速率。这种方法在临床研究中的应用将大大提高我们对胰岛素分泌的理解。
The studies reviewed in this article have indicated that C-peptide and insulin are cosecreted from the beta cell in equimolar concentration, that C-peptide does not undergo significant hepatic extraction, and that its MCR remains constant over the physiologic range of concentrations. Furthermore, the peripheral kinetics of distribution of C-peptide can be described by a two-compartment mathematical model. If model parameters are derived in individual subjects by analysis of C-peptide decay curves, this information can subsequently be used to derive insulin secretion rates with a great degree of accuracy from endogenously secreted C-peptide concentrations. The application of this approach to clinical research studies should greatly enhance our understanding of insulin secretion.