P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.
P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.
复制标题
P-OTX：垂体前叶发育期间表达的 PIT-1 相互作用同源域因子。
DOI：
10.1073/pnas.93.15.7706
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发表时间：
1996
影响因子：
11.1
通讯作者：
Rosenfeld,MG
中科院分区：
文献类型：
--
作者：
Szeto,DP;Ryan,AK;O'Connell,SM;Rosenfeld,MG
一种新型 OTX 相关同源域转录因子因其与垂体特异性 POU 结构域蛋白 Pit-1 的反式激活结构域相互作用的能力而被鉴定。该因子称为 P-OTX（垂体 OTX 相关因子），在原始 Rathke 囊、口腔上皮、第一支气管弓、十二指肠和后肢中表达。在发育中的垂体前叶中，它在所有区域表达，在成熟的腺体中将出现具有不同表型的细胞。 P-OTX 能够独立激活垂体特异性靶基因启动子上的 Pit-1 并与其协同作用。因此，P-OTX 可能有助于在垂体前叶和其他几个器官中产生前体细胞和特定细胞表型。
A novel OTX-related homeodomain transcription factor has been identified on the basis of its ability to interact with the transactivation domain of the pituitary-specific POU domain protein, Pit-1. This factor, referred to as P-OTX (pituitary OTX-related factor), is expressed in primordial Rathke's pouch, oral epithelium, first bronchial arch, duodenum, and hindlimb. In the developing anterior pituitary, it is expressed in all regions from which cells with distinct phenotypes will emerge in the mature gland. P-OTX is able to independently activate and to synergize with Pit-1 on pituitary-specific target gene promoters. Therefore, P-OTX may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs.