R-loop: The new genome regulatory element in plants
R-loop: The new genome regulatory element in plants
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DOI：
10.1111/jipb.13383
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发表时间：
2022
影响因子：
11.4
通讯作者：
Qianwen Sun
中科院分区：
文献类型：
--
作者：
Jincong Zhou;Weifeng Zhang;Qianwen Sun
An R-loop is a three-stranded chromatin structure that consists of a displaced singlestrand of DNA and an RNA:DNA hybrid duplex, which was thought to be a rare byproduct of transcription. However, recent genome-wide data have shown that R-loops are wide spread and pervasive in a variety of genomes, and a growing body of experimental evidence indicates that R-loops have both beneficial and harmful effects on an organism. To maximize benefit and avoid harm, organisms have evolved several means by which they tightly regulate R-loop levels. Here, we summarize our current understanding of the biogenesis and effects of R-loops, the mechanisms that regulate them, and methods of R-loops profiling, reviewing recent research advances on R-loops in plants. Furthermore, we provide perspectives on future research directions for R-loop biology in plants, which might lead to a more comprehensive understanding of R-loop functions in plant genome regulation and contribute to future agricultural improvements.
