Cutting edge:: Distinct roles for T help and CD40/CD40 ligand in regulating differentiation of proliferation-competent memory CD8+ T cells
Cutting edge:: Distinct roles for T help and CD40/CD40 ligand in regulating differentiation of proliferation-competent memory CD8+ T cells
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DOI：
10.4049/jimmunol.173.4.2217
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发表时间：
2004-08-15
影响因子：
4.4
通讯作者：
Oxenius, A
中科院分区：
文献类型：
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作者：
Bachmann, MF;Schwarz, K;Oxenius, A
小鼠原发抗病毒细胞毒性T细胞(M)反应通常是在没有Th细胞的情况下诱导的。在这项研究中，我们证明了病毒样颗粒，如果与富含CpG基序的DNA结合，在存在或不存在T Help的情况下，有效地触发初级CTL反应和类似频率的记忆CTL。然而，在缺乏T Help的情况下启动的记忆CTL在病毒攻击时未能增殖。然而，它们被有效地招募到炎症部位，表明T Help可能调节具有增殖能力和迁移能力的记忆MS之间的平衡。令人惊讶的是，具有增殖能力的记忆CTL的产生完全不依赖于CD40或CD40L，这两个分子通常被认为是介导Th细胞对CTL发育的有利影响的中心分子。因此，Th细胞而不是CD40/CD40L是分化具有增殖能力的中央记忆CD8(+)T细胞的关键。
Murine primary antiviral cytotoxic T cell (M) responses are often induced in the absence of Th cells. In this study, we show that virus-like particles, if combined with DNA rich in CpG motifs, efficiently trigger primary CTL responses and comparable frequencies of memory CTLs in the presence or absence of T help. However, memory CTLs primed in the absence of T help failed to proliferate upon viral challenge. Nevertheless, they were efficiently recruited to sites of inflammation, indicating that T help may regulate the balance between proliferation-competent and migration-competent memory Ms. Surprisingly, generation of proliferation-competent memory CTLs was completely independent of CD40 or CD40L, molecules commonly assumed to be central for mediating the beneficial effects of Th cells on CTL development. Thus, Th cells but not CD40/CD40L are key for the differentiation of proliferation-competent central memory CD8(+) T cells.