MIRD pamphlet No. 23: quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy.
MIRD pamphlet No. 23: quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy.
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DOI：
10.2967/jnumed.111.100123
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Ljungberg M
中科院分区：
文献类型：
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作者：
Dewaraja YK;Frey EC;Sgouros G;Brill AB;Roberson P;Zanzonico PB;Ljungberg M
在内部放射性核素治疗，体素水平估计的组织吸收剂量的兴趣日益增长的驱动下，希望报告的放射生物学量，占这些剂量估计的空间和时间的不均匀性的生物后果。本报告概述了三维SPECT方法和要求的内部剂量测定在区域和体素水平。联合SPECT/CT图像为基础的方法强调，因为CT衍生的解剖信息允许一个解决多个技术因素，影响SPECT定量，同时促进患者特定的体素水平剂量计算本身。放射性核素治疗中用于量化的SPECT成像和重建技术不一定与旨在优化诊断成像质量的技术相同。本综述旨在介绍即将推出的MIRD系列小册子，其中包含详细的放射性核素特定建议，旨在为放射性核素剂量测定提供基于SPECT定量的最佳实践指南。
In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologic consequences of both spatial and temporal nonuniformities in these dose estimates. This report presents an overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regional and voxel levels. Combined SPECT/CT image-based methods are emphasized, because the CT-derived anatomic information allows one to address multiple technical factors that affect SPECT quantification while facilitating the patient-specific voxel-level dosimetry calculation itself. SPECT imaging and reconstruction techniques for quantification in radionuclide therapy are not necessarily the same as those designed to optimize diagnostic imaging quality. The current overview is intended as an introduction to an upcoming series of MIRD pamphlets with detailed radionuclide-specific recommendations intended to provide best-practice SPECT quantification–based guidance for radionuclide dosimetry.