BEHAB/brevican: a brain-specific lectican implicated in gliomas and glial cell motility.
BEHAB/brevican: a brain-specific lectican implicated in gliomas and glial cell motility.
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BEHAB/brevican：一种与神经胶质瘤和神经胶质细胞运动有关的大脑特异性凝集素。
DOI：
10.1016/s0959-4388(98)80083-4
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发表时间：
1998
影响因子：
5.7
通讯作者：
Hockfield,S
中科院分区：
文献类型：
--
作者：
Gary,SC;Kelly,GM;Hockfield,S
最近的一些发现促进了我们对脑细胞外基质(ECM)的组成和功能的理解。BEHAB/brevican是最近发现的一种中枢神经系统特异性蛋白多糖，是脑ECM的组成部分，在胶质细胞运动过程中表达上调。它在发育过程中高水平表达，对损伤的反应，以及在原发脑瘤中表达。BEHAB/Brivican蛋白的裂解可能会增加肿瘤细胞的侵袭力。
Several recent findings have advanced our understanding of the composition and function of the brain extracellular matrix (ECM). BEHAB/brevican, a recently identified CNS-specific proteoglycan, is a component of the brain ECM and is upregulated during glial cell motility. It is expressed at high levels during development, in response to injury, and in primary brain tumors. Cleavage of the BEHAB/brevican protein may increase invasion of tumor cells.