Background adaptation in children with a history of mild retinopathy of prematurity.
Background adaptation in children with a history of mild retinopathy of prematurity.
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DOI：
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发表时间：
2000
影响因子：
4.4
通讯作者：
R. Hansen;A. Fulton
中科院分区：
文献类型：
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作者：
R. Hansen;A. Fulton
目的在有轻度早产儿视网膜病变(ROP)病史的儿童中，验证光感受器而不是感受器后功能障碍导致黄斑旁黄斑中心凹高于外周暗适应阈值的假设。方法采用强制选择程序测量阈值，检测直径2度，50毫秒，蓝色刺激在黑暗和稳定的红色背景(-4~+2log Scot Td)存在下偏心10度(中央凹旁)或30度(周边)。四名ROP受试者和四名对照组受试者在两种偏心状态下被测试。用增量阈值函数模型对实验数据进行拟合，计算了特征光阈值和暗适应阈值。结果两例ROP患者的黄斑旁阈值均升高，黄斑旁本征也升高。另一方面，在无黄斑旁阈值升高的ROP受试者中，黄斑旁和外周本征是相同的。然而，在这两个部位，所有ROP受试者的暗适应阈值都高于任何对照受试者。结论视乳头旁阈值升高是视杆功能障碍所致。也有证据表明ROP受试者外周视杆感光细胞受累。
PURPOSE In children with a history of mild retinopathy of prematurity (ROP), test the hypothesis that elevation of the parafoveal over peripheral dark-adapted threshold is due to photoreceptor rather than postreceptor dysfunction. METHODS A forced choice procedure was used to measure thresholds, for detection of 2 degrees diameter, 50 msec, blue stimuli presented 10 degrees (parafoveal) or 30 degrees (peripheral) eccentric in the dark and in the presence of steady red backgrounds (-4 to +2 log scot td). Four ROP and four control subjects were tested at both eccentricities. A model of the increment threshold function was fit to the data to calculate the eigengrau and dark-adapted threshold. RESULTS Both ROP subjects with elevated parafoveal thresholds also have elevated parafoveal eigengraus. On the other hand, parafoveal and peripheral eigengraus are equal in ROP subjects without parafoveal threshold elevation. Nevertheless, the dark-adapted thresholds of all ROP subjects are higher than those of any control subject at both sites. CONCLUSIONS The parafoveal threshold elevation is due to rod dysfunction. There is also evidence of peripheral rod photoreceptor involvement in the subjects with ROP.