Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response
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DOI：
10.1016/j.dsx.2020.04.020
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发表时间：
2020-07-01
影响因子：
10
通讯作者：
Ysrafil
中科院分区：
文献类型：
--
作者：
Astuti, Indwiani;Ysrafil
背景和目的：由于冠状病毒在世界各国的迅速传播，2020年3月11日，世卫组织发布公告，宣布2019年冠状病毒病由流行状态改为大流行状态。引起这种疾病的病毒被认为来自武汉一家活动物市场上交易的动物中国。严重急性呼吸综合征冠状病毒2可以攻击肺细胞，因为有许多保守的受体条目，即血管紧张素转换酶-2。这种病毒在宿主细胞中的存在将引发各种保护性反应，导致肺炎和急性呼吸窘迫综合征。方法：检索PubMed数据库，检索严重急性呼吸综合征冠状病毒2型、中东呼吸综合征相关冠状病毒和严重急性呼吸综合征冠状病毒。对全文进行检索、分析，形成通俗易懂的综述。结果：对病毒的结构、来源以及机体对病毒感染的反应进行了全面综述，并解释了免疫系统过度反应或细胞因子风暴的可能性。我们还解释了该病毒如何创建避免模式以逃避免疫系统攻击。我们进一步解释了在治疗和预防这种病毒感染方面可以采取的治疗方法。结论：综上所述，根据冠状病毒的结构和免疫逃避系统，我们提出了几种治疗方法。(C)2020年印度糖尿病。爱思唯尔有限公司出版。保留所有权利。
Background and aim: As a result of its rapid spread in various countries around the world, on March 11, 2020, WHO issued an announcement of the change in coronavirus disease 2019 status from epidemic to pandemic disease. The virus that causes this disease is indicated originating from animals traded in a live animal market in Wuhan, China. Severe Acute Respiratory Syndrome Coronavirus 2 can attack lung cells because there are many conserved receptor entries, namely Angiotensin Converting Enzyme-2. The presence of this virus in host cells will initiate various protective responses leading to pneumonia and Acute Respiratory Distress Syndrome. This review aimed to provide an overview related to this virus and examine the body's responses and possible therapies.Method: We searched PubMed databases for Severe Acute Respiratory Syndrome Coronavirus-2, Middle East respiratory syndrome-related coronavirus and Severe Acute Respiratory Syndrome Coronavirus. Full texts were retrieved, analyzed and developed into an easy-to-understand review.Results: We provide a complete review related to structure, origin, and how the body responds to this virus infection and explain the possibility of an immune system over-reaction or cytokine storm. We also include an explanation of how this virus creates modes of avoidance to evade immune system attacks. We further explain the therapeutic approaches that can be taken in the treatment and prevention of this viral infection.Conclusion: In summary, based on the structural and immune-evasion system of coronavirus, we suggest several approaches to treat the disease. (C) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.