E-CADHERIN EXPRESSION IN RENAL-CELL CANCER AND ITS SIGNIFICANCE IN METASTASIS AND SURVIVAL
E-CADHERIN EXPRESSION IN RENAL-CELL CANCER AND ITS SIGNIFICANCE IN METASTASIS AND SURVIVAL
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DOI：
10.1038/bjc.1995.76
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发表时间：
1995-02-01
影响因子：
8.8
通讯作者：
TOMITA, Y
中科院分区：
文献类型：
--
作者：
KATAGIRI, A;WATANABE, R;TOMITA, Y
E-钙粘附素(E-cd)是一种同型的细胞间黏附分子，其表达降低被认为是导致肿瘤细胞从原发灶脱落的原因，这是肿瘤转移的第一阶段。由于肾细胞癌(RCC)具有较高的转移频率，我们对肾癌中E-CD的表达及其临床病理意义进行了研究。采用免疫组织化学方法检测E-cd在正常肾组织和肾癌组织中的表达。在正常肾组织中，E-cd表达定位于远端小管和集合管。在肾癌中，106个原发灶中有20个表达E-CD(18.9%)，而8个转移灶中无一例表达E-CD。E-cd的表达缺失与肾癌的分期有统计学意义的相关性。经Kaplan-Meier分析，保留E-CD表达的患者预后优于无E-CD表达的患者(COX-MANTEL检验，P=0.022，平均随访32个月或死亡)。本研究提示E-cd表达降低的患者可能与转移有关，导致预后不良。而E-CD在肾癌中的表达频率低于其他肿瘤，这可能与E-CD在正常肾组织中的定位分布有关。
Decreased expression of E-cadherin (E-CD), a homotypic intercellular adhesion molecule, is considered to elicit detachment of tumour cells from primary lesions, which is the first stage of metastasis. Since renal cell cancer (RCC) shows a relatively high frequency of metastasis, we focused our interest on E-CD expression in RCC and its clinicopathological implications. We examined E-CD expression in normal kidney and RCC by immunohistochemical staining. In normal kidney, E-CD expression was localised in distal tubules and collecting ducts. In RCC, 20 of 106 primary lesions (18.9%) expressed E-CD, whereas none showed positive staining for eight metastatic lesions. There was a statistically significant correlation between loss of E-CD expression and advanced stages of RCC. Kaplan-Meier analysis showed better prognosis in the group with preserved E-CD expression than without E-CD expression (Cox-Mantel test, P = 0.022, the average follow-up was 32 months or until death). This study suggests that the patients with decreased E-CD expression may be associated with metastasis, resulting in poor prognosis. However, frequency of E-CD expression in RCC is lower than in other cancers, which may be derived from the localised distribution of E-CD expression in normal kidney.