Lessons from genetically engineered animal models X. Trefoil peptide and EGF receptor/ligand transgenic mice
Lessons from genetically engineered animal models X. Trefoil peptide and EGF receptor/ligand transgenic mice
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DOI：
10.1152/ajpgi.2000.278.4.g501
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发表时间：
2000-04-01
影响因子：
4.5
通讯作者：
Giraud, AS
中科院分区：
文献类型：
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作者：
Giraud, AS
使用具有功能获得和功能丧失突变的基因工程小鼠，对胃肠道的许多调节肽的正常和病理生理作用提供了特别的信息。本文综述了与表皮生长因子（EGF）受体及其配体相关的一些主要发现，特别是主要的肠道配体转化生长因子-or，以及三叶肽。这两个肽家族在维持组织稳态和损伤后修复方面都有重要的局部作用，当控制它们的调节机制被破坏时，它们可能有助于疾病的进展。未来转基因技术在这些领域的应用很可能在进一步加深我们对这些肽在健康和疾病中的生物学理解方面产生积极的影响。
The use of genetically engineered mice with both gain-of-function and loss-of-function mutations has been particularly informative about the normal and pathophysiological actions of a number of regulatory peptides of the gastrointestinal tract. This review highlights some of the major findings pertinent to the epidermal growth factor (EGF) receptor and its ligands, particularly the major gut ligand transforming growth factor-or, as well as the trefoil peptides. Both of these peptide families have important local actions in maintaining tissue homeostasis and repair after injury, and when mechanisms governing their regulation are disrupted they may contribute to disease progression. Future applications of transgenic technology to these areas are likely to be productive in furthering our understanding of the biology of these peptides in health and disease.