Role of small RNAs in host-microbe interactions.

Role of small RNAs in host-microbe interactions.
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DOI:
10.1146/annurev-phyto-073009-114457
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发表时间:
2010
影响因子:
10.2
通讯作者:
Jin H
Jin H
中科院分区:
农林科学1区
文献类型:
--
作者:
Katiyar-Agarwal S;Jin H

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植物对病原体的防御反应是由大量基因的激活和抑制介导的。宿主内源性小RNA在该基因表达重编程过程中是必不可少的。在这里,我们讨论了病原体调节的宿主microRNAs(miRNAs)和小干扰RNA(siRNA)及其在植物-微生物相互作用中的作用的最新研究结果。我们进一步介绍了小RNA途径的组成部分,包括Dicer样蛋白(DCL),双链RNA(dsRNA)结合蛋白,RNA依赖性RNA聚合酶(RDRs),小RNA甲基转移酶HEN 1和Argonaute(AGO)蛋白,有助于植物免疫反应。病原体已经发展到抑制宿主小RNA途径的策略也进行了讨论。总的来说,宿主小RNA和RNA沉默机制构成了调节病原体与植物相互作用的关键防御层。
Plant defense responses against pathogens are mediated by activation and repression of a large array of genes. Host endogenous small RNAs are essential in this gene expression reprogramming process. Here, we discuss recent findings on pathogen-regulated host microRNAs (miRNAs) and small interfering RNAs (siRNAs) and their roles in plant-microbe interaction. We further introduce small RNA pathway components, including Dicer-like proteins (DCLs), double-stranded RNA (dsRNA) binding protein, RNA-dependent RNA polymerases (RDRs), small RNA methyltransferase HEN1, and Argonaute (AGO) proteins, that contribute to plant immune responses. The strategies that pathogens have evolved to suppress host small RNA pathways are also discussed. Collectively, host small RNAs and RNA silencing machinery constitute a critical layer of defense in regulating the interaction of pathogens with plants.
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