In vivo cytological observation of liver and spleen by using high-resolution microendoscopy system under endoscopic ultrasound guidance: A preliminary study using a swine model.
In vivo cytological observation of liver and spleen by using high-resolution microendoscopy system under endoscopic ultrasound guidance: A preliminary study using a swine model.
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DOI：
10.4103/2303-9027.187867
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发表时间：
2016-07
影响因子：
4.5
通讯作者：
Bhutani MS
中科院分区：
文献类型：
--
作者：
Suzuki R;Shin D;Richards-Kortum R;Coghlan L;Bhutani MS
超声引导下的内镜下细针穿刺（EUS-FNA）对于获取肝脏和脾脏深层病变的标本是有用的。然而，必须探索新的辅助技术的发展，以减少该过程中针的次数和潜在的不良反应。我们利用猪进行了一项动物研究，以证明在EUS指导下使用高分辨率显微内镜（HRME）系统对肝脏和脾脏进行体内细胞学观察的技术可行性。我们成功地完成了这项研究。手术过程中未发生明显的急性不良事件。HRME系统可以获得清晰的反映脾脏和肝脏细胞学水平形态的图像。由此发现，在EUS引导下使用HRME系统进行肝脾的体内细胞学观察在技术上是可行的。
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is useful to obtain specimens from lesions underlying deep parts of the liver and spleen. However, the development of novel ancillary techniques must be explored to reduce the number of needle passes and potential adverse effects during this procedure. We conducted an animal study using a swine to demonstrate technical feasibility of in vivo cytological observation of liver and spleen using the high-resolution microendoscopy (HRME) system under EUS guidance. We successfully performed the study. No significant acute adverse events occurred during the procedure. The HRME system could obtain clear images representing cytology-level morphology of spleen and liver. Hence, it is found out that in vivo cytological observation of liver and spleen using the HRME system under EUS guidance is technically feasible.