Amino acid deletion at codon 67 and Thr-to-Gly change at codon 69 of human immunodeficiency virus type 1 reverse transcriptase confer novel drug resistance profiles
Amino acid deletion at codon 67 and Thr-to-Gly change at codon 69 of human immunodeficiency virus type 1 reverse transcriptase confer novel drug resistance profiles
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DOI：
10.1128/jvi.75.8.3988-3992.2001
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发表时间：
2001-04-01
影响因子：
5.4
通讯作者：
Lane, HC
中科院分区：
文献类型：
--
作者：
Imamichi, T;Murphy, MA;Lane, HC
研究了人类免疫缺陷病毒（HIV）1型逆转录酶67位密码子缺失（Δ 67）和69位密码子由Thr变为Gly（T69 G）在药物敏感性和相对复制适合度中的潜在规律。我们的研究结果表明，Delta 67和T69 G的变化可以归类为与多药耐药相关的突变。两种突变与L74 I变化的组合（Δ 67+ T69 G/L74 I）导致新的3 '-叠氮基-3'-脱氧胸苷抗性基序，并补偿受损的HIV复制。
The potential rules of an amino acid deletion at codon 67 (Delta 67) and a Thr-to-Gly change at codon 69 (T69G) in the reverse transcriptase of human immunodeficiency virus (HIV) type 1 in drug sensitivity and relative replication fitness were studied. Our results suggest that the Delta 67 and T69G changes can be categorized as mutations associated with multidrug resistance. The combination of both mutations with an L74I change (Delta 67+T69G/L74I) leads to a novel 3'-azido-3'-deoxythymidine resistance motif and compensates for impaired HIV replication.