Homeobox gene Sax2 deficiency causes an imbalance in energy homeostasis.
Homeobox gene Sax2 deficiency causes an imbalance in energy homeostasis.
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同源框基因 Sax2 缺陷会导致能量稳态失衡。
DOI：
10.1002/dvdy.21320
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Bergemann,AndrewD
中科院分区：
文献类型：
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作者：
Simon,Ruth;Lufkin,Thomas;Bergemann,AndrewD
大脑，特别是下丘脑和脑干，通过整合来自外周的信号并将其转化为进食行为，在能量稳态的调节中起着关键作用。在这里，我们表明，同源框基因Sax 2，这是主要在脑干中表达，在肾上腺素能神经元附近，有助于这种生理平衡。Sax 2缺乏导致减少脂肪和糖原储存，降低血糖水平，并提高血清素水平在后脑。令人惊讶的是，在脑干中，阿黑皮素原和神经肽Y的表达水平表明禁食状态，而不是观察到的暗示饱足的高血清素水平。此外，Sax 2定向lacZ表达揭示了在围产期发育期间发生的无效突变体中Sax 2表达细胞的分布的戏剧性变化。这些数据有力地表明，Sax 2是参与维持能量稳态的因素的协调串扰所必需的。发展动力学236：2792-2799，2007年。© 2007 Wiley利斯公司
The brain, in particular the hypothalamus and the brainstem, plays a critical role in the regulation of energy homeostasis by incorporating signals from the periphery and translating them into feeding behavior. Here we show that the homeobox geneSax2, which is expressed predominantly in the brainstem, in the vicinity of serotonergic neurons, contributes to this physiological balance.Sax2deficiency results in a decrease of fat and glycogen storage, reduced blood glucose levels, and raised serotonin levels in the hindbrain. Surprisingly, in the brainstem the expression levels of pro‐opiomelanocortin and neuropeptide Y were indicative of a fasting condition, opposed to the observed high serotonin levels implying satiation. Furthermore,Sax2‐directedlacZexpression reveals a dramatic change of the distribution ofSax2‐expressing cells in the null mutant occurring during perinatal development. These data strongly suggest thatSax2is required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis. Developmental Dynamics 236:2792–2799, 2007. © 2007 Wiley‐Liss, Inc.