REVERSAL OF 5-FLUOROURACIL-INDUCED TOXICITY BY ORAL-ADMINISTRATION OF URIDINE
REVERSAL OF 5-FLUOROURACIL-INDUCED TOXICITY BY ORAL-ADMINISTRATION OF URIDINE
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DOI：
10.1093/oxfordjournals.annonc.a058490
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发表时间：
1993-04-01
影响因子：
50.5
通讯作者：
PINEDO, HM
中科院分区：
文献类型：
--
作者：
VANGROENINGEN, CJ;PETERS, GJ;PINEDO, HM
背景资料：先前的临床前和临床研究表明，5-氟尿嘧啶（5-FU）与延迟尿苷联合给药可以逆转5-FU诱导的副作用。这种基于生化调节的组合可以增加5-FU的治疗指数。7例晚期癌症患者每周接受一次5-FU治疗，剂量从600 mg/m2开始递增。5例患者发生剂量限制性白细胞减少症，2例患者发生血小板减少症。在剂量限制性毒性水平下，重复5-FU治疗，3小时后口服尿苷（5 g/m2 q 6 hr），持续72 h.Results：5-FU诱导的白细胞减少在口服尿苷后数周内逆转。然而，血小板减少症未逆转。联合治疗的副作用包括轻度腹泻的7 patients.Conclusions：这些数据表明，口服尿苷可以降低5-FU诱导的骨髓抑制的严重程度。
Background: Previous preclinical and clinical investigations have shown that the combined administration of 5-fluorouracil (5-FU) with delayed uridine can reverse side effects induced by 5-FU. This biochemical modulation-based combination may increase the therapeutic index of 5-FU.Patients and methods. Seven patients with advanced cancer were treated weekly with 5-FU at increasing dosages starting at a dose of 600 mg/m2. Five patients developed dose-limiting leukopenia, and two patients developed thrombocytopenia. At the dose-limiting toxicity level, 5-FU treatment was repeated and followed after 3 hours by oral uridine (5 g/m2 q 6 hr) during 72 hours.Results: 5-FU-induced leukopenia was reversed for several weeks after the administration of oral uridine. However, thrombocytopenia was not reversed. Side effects of the combined treatment consisted of mild diarrhea in five of the seven patients.Conclusions: These data indicate that oral uridine can reduce the severity of 5-FU-induced myelosuppression.