Hydralazine prevents changes in the contractile response of aortic but not portal vein strips in hypertensive rats.
Hydralazine prevents changes in the contractile response of aortic but not portal vein strips in hypertensive rats.
复制标题
肼屈嗪可防止高血压大鼠主动脉收缩反应的变化，但不能防止门静脉条的变化。
DOI：
10.1159/000158260
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
M. Sutter
中科院分区：
文献类型：
--
作者：
C. Pang;M. Sutter
先前的研究表明，自发性（SHR）或DOCA/盐诱导的高血压大鼠的主动脉条带与正常大鼠的主动脉条带相比，对去甲肾上腺素（NA）的应激（力/面积）更小。与对照大鼠相比，来自SHR的门静脉条对NA产生更大的作用力，而来自DOCA/盐性高血压大鼠的门静脉条则没有。我们已经研究了肼是否可以预防这些变化。一组大鼠从DOCA治疗第一天起，在1% NAC1的饮水液中加入海拉嗪。第二组在13周龄SHR的饮水中添加肼嗪。用肼嗪治疗3周后，利用肼嗪治疗大鼠和对照大鼠的主动脉和门静脉条研究其与NA的累积剂量-反应关系。海达拉嗪对SHR大鼠和DOCA/salt大鼠主动脉条带对NA的应激和动脉压升高均有抑制作用。并不能阻止SHR引起的门静脉条带向NA发展的力的增加。因此，高血压大鼠主动脉条收缩反应的降低似乎是高血压的结果，因为血压升高和主动脉反应的降低都是由肼嗪预防的。SHR引起的门静脉条收缩反应增加似乎与血压无关。
Previous studies showed that aortic strips from rats with either spontaneous (SHR) or DOCA/salt-induced hypertension developed less stress (force/area) in response to noradrenaline (NA) when compared to aortic strips from normotensive rats. Portal vein strips from SHR, but not from DOCA/salt hypertensive rats, developed greater force to NA compared to strips from control rats. We have investigated whether these changes are prevented by hydralazine. Hydralazine was added to the drinking solution (1% NAC1) of one group of rats from the first day of treatment with DOCA. In the second group, hydralazine was added to the drinking water of 13-week-old SHR. After 3 weeks of treatment with hydralazine, cumulative dose-response relationships to NA were studied using aortic and portal vein strips from hydralazine-treated and control rats. Hydralazine prevented the increase of arterial pressure and the decrease of stress developed to NA by the aortic strips from both SHR and DOCA/salt rats. It did not prevent the increase of force developed to NA by the portal vein strips from SHR. Thus, reduced contractile response of the aortic strips from hypertensive rats seems to be the result of a high pressure, since both the rise in blood pressure and reduced aortic response are prevented by hydralazine. Increased contratile response of the portal vein strips from SHR appears to be independent of blood pressure.