Production of Laudanosine Following Infusion of Atracurium in Man and Its Effects on Awakening
Production of Laudanosine Following Infusion of Atracurium in Man and Its Effects on Awakening
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人输注阿曲库铵后劳丹诺辛的产生及其对觉醒的影响
DOI：
10.1093/bja/63.1.76
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
D. Crankshaw
中科院分区：
文献类型：
--
作者：
G. Beemer;A. Bjorksten;P. Dawson;D. Crankshaw
20例患者在手术期间通过输注给予最大剂量的阿曲库铵或维库溴铵。通过输注硫喷妥钠、笑气和芬太尼维持麻醉。在给予阿曲库铵的患者中，手术停止时的血浆劳丹诺新浓度为0.34（SD 0.22）μ g ml-1;手术期间几乎没有蓄积趋势。在给予阿曲库铵的患者中，发现觉醒时硫喷妥钠的动脉浓度高出20%，表明劳丹诺新刺激了CNS，尽管这种作用太温和而没有临床意义。
Twenty patients were given maximal doses of atracurium or vecuronium by infusion during surgery. Anaesthesia was maintained with an infusion of thiopentone, nitrous oxide and fentanyl. In patients administered atracurium, the plasma laudanosine concentration at cessation of surgery was 0.34 (SD 0.22) micrograms ml-1; there was little tendency to cumulate during operation. A 20% higher arterial concentration of thiopentone was found at awakening in patients given atracurium, suggesting CNS stimulation by laudanosine, although the effect is too modest to be of clinical significance.