Transformation of Apatite Cement to B-Type Carbonate Apatite Using Different Atmosphere
Transformation of Apatite Cement to B-Type Carbonate Apatite Using Different Atmosphere
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不同气氛下磷灰石水泥向B型碳酸盐磷灰石的转化
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
K. Ishikawa
中科院分区：
文献类型：
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作者：
Arief Cahyanto;K. Tsuru;K. Ishikawa
磷灰石骨水泥（AC）是骨缺损修复生物材料的一个突破。然而，到目前为止，AC替代骨对于研究者来说仍然是有争议的。一些研究人员报告称，AC被骨替代，而其他人则声称替代有限。研究了不同气氛下AC向B型碳酸磷灰石（CO 3Ap）的转化机理。采用模拟人体环境的体外研究，以检查凝固气氛对凝固AC组成的影响。使与蒸馏水混合的等摩尔的磷酸四钙（TTCP; Ca 4（PO 4）2 O）和无水磷酸二钙（DCPA; CaHPO 4）能够在37 ℃和100%相对湿度下在5%CO2、100%CO2和100%N2气氛存在下硬化。XRD和FT-IR分析表明，在100%CO2和5%CO2的存在下，可以确定B型CO 3Ap，只有少量的TTCP未反应。相反，在100%N2的存在下，与5%CO2和100%CO2气氛相比，CO 32-带不能被检测到，并且更大量的TTCP保持未反应。SEM形貌显示AC的微观结构相互缠结、相互锁定。另外，在100%N2气氛中，表面出现了类似于羟基磷灰石的针状晶体。我们认为，在固化反应过程中，AC中的CO 32-离子可能是CO 3Ap形成的重要因素之一。
Apatite cement (AC) is a breakthrough in biomaterials for the reconstruction of the bone defect. However, the replacement of AC to bone up to the present time is still controversial for researchers. Several researchers have reported that AC was replaced by bone while others claimed replacement was limited. The aim of this study is to investigate the transformation mechanism of AC to B-type carbonate apatite (CO3Ap) using different atmosphere. An in vitro study mimicking the body environment was employed in order to examine the effect of setting atmosphere on the composition of set AC. An equimolar of tetracalcium phosphate (TTCP; Ca4(PO4)2O) and dicalcium phosphate anhydrous (DCPA; CaHPO4) mixed with distilled water was enabled to harden at 37°C and 100% of relative humidity under presence of 5% CO2, 100% CO2, and 100% N2 atmospheres. XRD and FT-IR analyses revealed that in the presence of 100% CO2 and 5% CO2, B-type CO3Ap could be determined and only small amounts of TTCP remained unreacted. On the contrary, in the presence of 100% N2, the CO32- bands could not be detected and larger amount of TTCP remained unreacted compared to 5% CO2and 100% CO2 atmospheres. SEM morphology showed that the microstructure of AC was entangled and locked to each other. In addition, the small needle like crystals appeared in the surface of 100% N2, similar to hydroxyapatite. We concluded that the CO32- ions incorporated in AC during setting reaction may be one of the essential factors for CO3Ap formation.
DOI：
10.1002/(sici)1097-4636(199824)43:4
发表时间：
1998-12-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
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作者：
Friedman, CD;Costantino, PD;Chow, LC
通讯作者：
Chow, LC