Thrombin signalling and protease-activated receptors
Thrombin signalling and protease-activated receptors
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DOI：
10.1038/35025229
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发表时间：
2000-09-14
期刊：
影响因子：
64.8
通讯作者：
Coughlin, SR
中科院分区：
文献类型：
--
作者：
Coughlin, SR
凝血蛋白酶凝血酶如何调节细胞行为？蛋白酶激活受体（PARs）提供了一个答案。与凝血级联反应相一致，这些受体提供了一种将组织损伤或血管渗漏形式的机械信息与细胞反应联系起来的优雅机制。PAR的作用开始出现在止血和血栓形成，炎症，甚至可能是血管的发展。
How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.