Lifestyle Intervention for Prevention of Type 2 Diabetes in Primary Health Care One-year follow-up of the Finnish National Diabetes Prevention Program (FIN-D2D)
Lifestyle Intervention for Prevention of Type 2 Diabetes in Primary Health Care One-year follow-up of the Finnish National Diabetes Prevention Program (FIN-D2D)
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DOI：
10.2337/dc10-0410
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发表时间：
2010-10-01
期刊：
影响因子：
16.2
通讯作者：
Keinanen-Kiukaanniemi, Sirkka
中科院分区：
文献类型：
--
作者：
Saaristo, Timo;Moilanen, Leena;Keinanen-Kiukaanniemi, Sirkka
目的 - 调查芬兰国家糖尿病预防计划的 1 年结果。 研究设计和方法 - 通过芬兰糖尿病风险评分 (FINDRISC；评分 >= 15 分)，根据 400 个初级卫生保健中心的空腹血糖受损 (IFG) 或糖耐量受损 (IGT)、心血管疾病或妊娠糖尿病病史，总共确定了 10,149 名糖尿病高危人群。中心。 2,798 名基线时未患有糖尿病的参与者（919 名男性和 1,879 名女性，年龄分别为 56.0 +/- 9.9 和 54.0 +/- 10.7 岁 [平均值 +/- SD]，BMI 为 30.9 +/- 4.6 和 31.6 +/- 5.4 kg/m(2)）提供了一年随访数据。 结果 糖尿病发病率为 2.0基线时糖耐量正常的男性和女性中，这一比例分别为 1.2% 和 1.2%；IFG 患者中，这一比例分别为 13.5% 和 7.4%；IGT 患者中，这一比例分别为 16.1% 和 11.3%。总共 17.5% 的受试者体重减轻了 >= 5%，没有性别差异。与保持体重的组相比，体重减轻>= 5%的组患糖尿病的相对风险为0.31 (95% CI 0.16-0.59)，体重减轻2.5-4.9%的组为0.72 (0.46-1.13)，体重增加>= 2.5%的组为1.10 (0.77-1.58)。 结论 - FIN-D2D 是第一个在初级卫生保健环境中实施预防的国家努力。招募高风险受试者的方法简单易用。在这个高危人群中，适度减轻体重对于降低参与该计划的人患糖尿病的风险特别有效。
OBJECTIVE - To investigate 1-year outcomes of a national diabetes prevention program in Finland.RESEARCH DESIGN AND METHODS - Altogether 10,149 individuals at high risk for diabetes were identified with the Finnish Diabetes Risk Score (FINDRISC; scoring >= 15 points), by a history of impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), cardiovascular disease, or gestational diabetes mellitus in 400 primary health care centers. One-year follow-up data were available for 2,798 participants who were nondiabetic at baseline (919 men and 1,879 women, aged 56.0 +/- 9.9 and 54.0 +/- 10.7 years [mean +/- SD] with BMI 30.9 +/- 4.6 and 31.6 +/- 5.4 kg/m(2)).RESULTS The incidence of diabetes was 2.0 and 1.2% in men and women with normal glucose tolerance at baseline, 13.5 and 7.4% in those with IFG, and 16.1 and 11.3% in those with IGT, respectively. Altogether 17.5% of the subjects lost >= 5% weight with no sex difference. The relative risk of diabetes was 0.31 (95% CI 0.16-0.59) in the group who lost >= 5% weight, 0.72 (0.46-1.13) in the group who lost 2.5-4.9% weight, and 1.10 (0.77-1.58) in the group who gained >= 2.5% compared with the group who maintained weight.CONCLUSIONS - The FIN-D2D was the first national effort to implement the prevention of in a primary health care setting. Methods for recruiting high-risk subjects were simple and easy to use. Moderate weight loss in this very high-risk group was especially effective in reducing risk of diabetes among those participating in the program.