Enhanced expression of the N-myc gene in Wilms' tumors.
Enhanced expression of the N-myc gene in Wilms' tumors.
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DOI：
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发表时间：
1986-12
期刊：
影响因子：
11.2
通讯作者：
P. Nisen;K. Zimmerman;S. Cotter;F. Gilbert;F. Alt
中科院分区：
文献类型：
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作者：
P. Nisen;K. Zimmerman;S. Cotter;F. Gilbert;F. Alt
myc家族癌基因的激活与多种肿瘤的发生有关。此外，这些基因在小鼠发育过程中表现出特定的表达模式。我们现在报道N-和c-myc在正常发育的人肾组织和Wilms肿瘤（一种源自原始肾细胞的肿瘤）中有差异表达。13个Wilms肿瘤中有12个在没有基因扩增的情况下表现出显著的表达水平增强。我们还在其他原始肿瘤中检测到N-myc的表达，包括髓母细胞瘤和肝母细胞瘤。我们的观察结果表明，N-myc的表达并不像以前认为的那样局限于神经外胚层肿瘤，而是源于原始细胞前体的几种肿瘤的标志物。最后，N-myc高水平表达与c-myc水平显著降低相关，提示N-myc基因表达增强可能导致c-myc下调。
Activation of myc-family oncogenes has been implicated in the genesis of a variety of neoplasms. In addition, these genes exhibit specific patterns of expression during murine development. We now report that N- and c-myc are differentially expressed in normal developing human renal tissues and in Wilms' tumor, a neoplasm which derives from primitive kidney cells. Twelve of 13 Wilms' tumors tested exhibited greatly enhanced levels of expression which occurred in the absence of gene amplification. We also detected N-myc expression in other primitive neoplasms including medulloblastoma and hepatoblastoma. Our observations suggest that N-myc expression is not limited to neuroectodermal tumors as was previously thought, but is a marker for several neoplasms that derive from primitive cell precursors. Finally, high level expression of N-myc was associated with markedly diminished levels of c-myc, suggesting that enhanced expression of N-myc gene might lead to down-regulation of c-myc.