Intact global cognitive and olfactory ability predicts lack of transition to dementia
Intact global cognitive and olfactory ability predicts lack of transition to dementia
复制标题
DOI：
10.1016/j.jalz.2019.08.200
复制
发表时间：
2020-02-01
影响因子：
14
通讯作者：
Mayeux, Richard
中科院分区：
文献类型：
--
作者：
Devanand, Davangere P.;Lee, Seonjoo;Mayeux, Richard
引言：气味识别缺陷是阿尔茨海默病和其他痴呆症的特征。我们研究了如果完整的性能，简短的认知和气味识别测试预测缺乏过渡到dementia.Methods：在城市社区，1037老年人没有痴呆症完成了40项宾夕法尼亚大学的识别测试，其中包括12项简短的识别测试（B-SIT）。从749名参与者随访4 years的数据进行了analyzed.Results：在协变量调整后的生存分析，减值的祝福方向记忆集中测试和B-SIT每个预测痴呆症（n = 109），主要是阿尔茨海默病（n = 101）。在嗅觉完整的参与者中，（B-SIT = 11/12正确）和认知（幸福方向记忆集中测试= 5/28不正确）能力，3.4%（4/117）在随访期间转变为痴呆，在70-75岁和81-83岁年龄组四分位数中没有转变。气味识别测试为全球认知测试增添了价值，并且可以识别很少转变为痴呆症的个体，从而避免不必要的诊断调查。
Introduction: Odor identification deficits characterize Alzheimer's disease and other dementias. We examined if intact performance on brief cognitive and odor identification tests predicts lack of transition to dementia.Methods: In an urban community, 1037 older adults without dementia completed the 40-item University of Pennsylvania Smell Identification Test, which includes the 12item Brief Smell Identification Test (B-SIT). Data from 749 participants followed up for 4 years were analyzed.Results: In covariate-adjusted survival analyses, impairment on the Blessed Orientation Memory Concentration Test and B-SIT each predicted dementia (n = 109), primarily Alzheimer's disease (n = 101). Among participants with intact olfactory (B-SIT = 11/12 correct) and cognitive (Blessed Orientation Memory Concentration Test = 5/28 incorrect) ability, 3.4% (4/117) transitioned to dementia during follow-up with no transitions in the 70-75 and 81-83 years age group quartiles.Discussion: Odor identification testing adds value to global cognitive testing, and together can identify individuals who rarely transition to dementia, thereby avoiding unnecessary diagnostic investigation.